The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2023.
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| Լեզու: | English |
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Brac University
2024
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| Առցանց հասանելիություն: | http://hdl.handle.net/10361/23037 |
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10361-230372024-06-02T21:02:32Z The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria Rafa, Zarin Tasnim Rini, Shadhin Chowdhury Hossain, Mohammed Mahboob Department of Mathematics and Natural Sciences, Brac University Antimicrobial resistance Gram-negative bacteria MIC FICI Drug resistance in microorganisms Gram-negative bacterial infections This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2023. Catalogued from PDF version of thesis. Includes bibliographical references (pages 72-77). Antibiotic resistance has become a major cause of superinfection and mortality globally. Combination therapy can be used to treat multi-drug-resistant Gram-negative bacteria. Vitamin C can be used in combination with antibiotics. In this study, the effects of combination of an antibiotic and Vitamin C, whether it be synergistic, antagonistic, or additive on multi-drug resistant Gam-negative bacteria were investigated. It was observed that the combination of Ciprofloxacin and Vitamin C showed a synergistic effect on the inhibition of bacterial growth. For Pseudomonas koreensis, the mean MIC of the combination was 30 μg/mL (CIP:15 μg/mL, Vitamin C:15 μg/ml) and the mean FICI was 0.47. For Escherichia fergusonii, the mean MIC of the combination was 22.5 μg/mL (CIP:7.5 μg/Ml, Vitamin C:15 μg/mL) and the mean FICI was 0.48. For another strain of P.koreensis, the mean MIC of the combination was 55 μg/mL (CIP:22.5 μg/Ml, Vitamin C:32.5 μg/mL) and the mean FICI was 0.49 Lastly for Enterobacter sichuanensis mean MIC of the combination was 50 μg/mL (CIP:17.5 μg/Ml, Vitamin C:32.5 μg/mL) and the mean FICI was 0.41. Since all the mean FICIs were within 0.5, the combination was found synergistic on these bacteria. Zarin Tasnim Rafa Shadhin Chowdhury Rini B. Biotechnology 2024-06-02T03:52:07Z 2024-06-02T03:52:07Z ©2023 2023-09 Thesis ID 19136024 ID 20136054 http://hdl.handle.net/10361/23037 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 91 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antimicrobial resistance Gram-negative bacteria MIC FICI Drug resistance in microorganisms Gram-negative bacterial infections |
| spellingShingle |
Antimicrobial resistance Gram-negative bacteria MIC FICI Drug resistance in microorganisms Gram-negative bacterial infections Rafa, Zarin Tasnim Rini, Shadhin Chowdhury The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2023. |
| author2 |
Hossain, Mohammed Mahboob |
| author_facet |
Hossain, Mohammed Mahboob Rafa, Zarin Tasnim Rini, Shadhin Chowdhury |
| format |
Thesis |
| author |
Rafa, Zarin Tasnim Rini, Shadhin Chowdhury |
| author_sort |
Rafa, Zarin Tasnim |
| title |
The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| title_short |
The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| title_full |
The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| title_fullStr |
The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| title_full_unstemmed |
The combined effects of ciprofloxacin and vitamin C on the multi drug resistant Gram-negative bacteria |
| title_sort |
combined effects of ciprofloxacin and vitamin c on the multi drug resistant gram-negative bacteria |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23037 |
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