Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Accés en línia: | http://hdl.handle.net/10361/22990 |
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10361-229902024-05-29T21:02:42Z Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis Islam, Inaya Sharmin, Shahana School of Pharmacy, Brac University NSCLC Paclitaxel Cisplatin Gemcitabine Vinorelbine Meta-analysis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 26-31). Introduction: The aim of the study is to assess the efficacy of cisplatin combinations with paclitaxel, gemcitabine and vinorelbine for the first line treatment of non-small cell lung cancer.Methods: The Cochrane library, PubMed. ClinicalTrials.gov were used to retrieve report. The included clinical trials and randomized controlled trials (RCT) were evaluated for hazard ratios of the overall survival (OS) and Progression Free Survival (PFS). The statistical analysis was performed using JASP and CMA. PRISMA guidelines were used to evaluate themethodology. Results: The hazard ratio found for CV, CG and CP are 0.76 (0.68,0.84), 0.88 (0.79,0.97) and 0.81 (0.65,0.97) respectively for OS and 0.71 (0.47,0.96), 0.69 (0.43,0.96) and = 0.65 (0.53,0.77) for PFS respectively. The hazard ratio of the subgroup analysis of OS and PFS ofall combinations is HR = 0.825 ( 0.806,0.894) and HR =0.694 (0.563,0.856) respectively. Conclusions: cisplatin combined with vinorelbine, gemcitabine, and paclitaxel have shown statically significant improved efficacy and safety in terms of treatment of NSCLC as compared to other available treatments Inaya Islam B. Pharmacy 2024-05-29T06:50:37Z 2024-05-29T06:50:37Z 2023 2023-06 Thesis ID 19146026 http://hdl.handle.net/10361/22990 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 31 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
NSCLC Paclitaxel Cisplatin Gemcitabine Vinorelbine Meta-analysis |
| spellingShingle |
NSCLC Paclitaxel Cisplatin Gemcitabine Vinorelbine Meta-analysis Islam, Inaya Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Sharmin, Shahana |
| author_facet |
Sharmin, Shahana Islam, Inaya |
| format |
Thesis |
| author |
Islam, Inaya |
| author_sort |
Islam, Inaya |
| title |
Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| title_short |
Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| title_full |
Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| title_fullStr |
Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| title_full_unstemmed |
Safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| title_sort |
safety and efficacy of cisplatin combinations with vinorelbine, paclitaxel and gemcitabine – a systematic review and meta-analysis |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22990 |
| work_keys_str_mv |
AT islaminaya safetyandefficacyofcisplatincombinationswithvinorelbinepaclitaxelandgemcitabineasystematicreviewandmetaanalysis |
| _version_ |
1814308342095413248 |