A review on the emerging role of SIRT6 in cardiovascular diseases

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.

Bibliographic Details
Main Author:	Dinar, Md. ShahOwaly Ullah
Other Authors:	Akter, Raushanara
Format:	Thesis
Language:	English
Published:	Brac University 2024
Subjects:	Hypertension Polypill Revascularization Bradyarrhythmia Atherogenesis Cardiovascular Diseases
Online Access:	http://hdl.handle.net/10361/22982

id	10361-22982
record_format	dspace
spelling	10361-229822024-05-29T21:00:46Z A review on the emerging role of SIRT6 in cardiovascular diseases Dinar, Md. ShahOwaly Ullah Akter, Raushanara School of Pharmacy, Brac University Hypertension Polypill Revascularization Bradyarrhythmia Atherogenesis Cardiovascular Diseases This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 34-54). The fundamental reasons behind cardiovascular diseases are exacerbated by a vast number of signaling molecules. Sirtuin 6 (SIRT6) is a highly conserved NAD+dependent enzyme and essential in regulating a number of cellular events, including telomeric balance, gene expression, DNA repair as well as management of metabolism. As a matter of importance, SIRT6 not only aids in atherosclerosis and cardiac remodelling but also protects against the onset and progression of CVDs. Hypertrophy of cardiomyocytes, atherosclerosis, and fibroblast transformation are all suppressed by SIRT6. When it comes to the beginning and progression of different cardiovascular illnesses, the involvement of SIRT6 in glucose and lipid balance, genomic stability, and inflammation are crucial. This study provides a detail discussion on existing molecular mechanism, prevention as well as available treatment and prospective therapeutic modulators to control SIRT6-mediated CVDs. Md. ShahOwaly Ullah Dinar B. Pharmacy 2024-05-29T05:05:08Z 2024-05-29T05:05:08Z 2023 2023-05 Thesis ID 18346028 http://hdl.handle.net/10361/22982 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 59 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	Hypertension Polypill Revascularization Bradyarrhythmia Atherogenesis Cardiovascular Diseases
spellingShingle	Hypertension Polypill Revascularization Bradyarrhythmia Atherogenesis Cardiovascular Diseases Dinar, Md. ShahOwaly Ullah A review on the emerging role of SIRT6 in cardiovascular diseases
description	This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
author2	Akter, Raushanara
author_facet	Akter, Raushanara Dinar, Md. ShahOwaly Ullah
format	Thesis
author	Dinar, Md. ShahOwaly Ullah
author_sort	Dinar, Md. ShahOwaly Ullah
title	A review on the emerging role of SIRT6 in cardiovascular diseases
title_short	A review on the emerging role of SIRT6 in cardiovascular diseases
title_full	A review on the emerging role of SIRT6 in cardiovascular diseases
title_fullStr	A review on the emerging role of SIRT6 in cardiovascular diseases
title_full_unstemmed	A review on the emerging role of SIRT6 in cardiovascular diseases
title_sort	review on the emerging role of sirt6 in cardiovascular diseases
publisher	Brac University
publishDate	2024
url	http://hdl.handle.net/10361/22982
work_keys_str_mv	AT dinarmdshahowalyullah areviewontheemergingroleofsirt6incardiovasculardiseases AT dinarmdshahowalyullah reviewontheemergingroleofsirt6incardiovasculardiseases
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A review on the emerging role of SIRT6 in cardiovascular diseases

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