Exploring the potential of organic molecules in the treatment of covid-19

This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021.

Bibliographic Details
Main Author:	Mondol, Winifred Claire
Other Authors:	Islam, Zubaida Marufee
Format:	Thesis
Language:	English
Published:	Brac University 2024
Subjects:	Molecular docking Mpro SARS-CoV-2 COVID-19 treatment COVID-19 (Disease) > Complications > Treatment. Molecules > Models SARS (Disease) COVID-19 (Disease)
Online Access:	http://hdl.handle.net/10361/22829

id	10361-22829
record_format	dspace
spelling	10361-228292024-05-15T21:02:19Z Exploring the potential of organic molecules in the treatment of covid-19 Mondol, Winifred Claire Islam, Zubaida Marufee Department of Mathematics and Natural Sciences, Brac University Molecular docking Mpro SARS-CoV-2 COVID-19 treatment COVID-19 (Disease)--Complications--Treatment. Molecules--Models SARS (Disease) COVID-19 (Disease) This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021. Cataloged from PDF version of thesis. Includes bibliographical references (pages 24-38). The novel pathogen SARS-CoV2 causing coronavirus disease 2019 (COVID-19) is a global public health concern. COVID-19 has infected over 220 million people worldwide so far. The study and development of novel bioactive chemicals with cost-effective and selective anti- COVID 19 therapeutic power is the primary focus of contemporary medical research. As a result, utilizing the molecular docking technique has become critical in the discovery and development of novel medications. The purpose of this work is to investigate the binding affinity and type of interactions between 30 chemical molecules and Mpro using molecular docking. Using UCSFChimera, the PDB data of the target protein and prepared organic molecules (ligands) were docked using AutoDockVina, which provides a set of potential complexes based on the criteria of form complementarity of the natural molecules with their binding affinities. According to the results, hyperoside, aloin, and ginkgetin, were found to have a high affinity with Mpro. Hence, these chemicals have the potential to be used as therapeutics against SARS-CoV2. Winifred Claire Mondol M. Biotechnology 2024-05-15T04:24:22Z 2024-05-15T04:24:22Z ©2021 2021-09 Thesis ID 19176015 http://hdl.handle.net/10361/22829 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 51 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	Molecular docking Mpro SARS-CoV-2 COVID-19 treatment COVID-19 (Disease)--Complications--Treatment. Molecules--Models SARS (Disease) COVID-19 (Disease)
spellingShingle	Molecular docking Mpro SARS-CoV-2 COVID-19 treatment COVID-19 (Disease)--Complications--Treatment. Molecules--Models SARS (Disease) COVID-19 (Disease) Mondol, Winifred Claire Exploring the potential of organic molecules in the treatment of covid-19
description	This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021.
author2	Islam, Zubaida Marufee
author_facet	Islam, Zubaida Marufee Mondol, Winifred Claire
format	Thesis
author	Mondol, Winifred Claire
author_sort	Mondol, Winifred Claire
title	Exploring the potential of organic molecules in the treatment of covid-19
title_short	Exploring the potential of organic molecules in the treatment of covid-19
title_full	Exploring the potential of organic molecules in the treatment of covid-19
title_fullStr	Exploring the potential of organic molecules in the treatment of covid-19
title_full_unstemmed	Exploring the potential of organic molecules in the treatment of covid-19
title_sort	exploring the potential of organic molecules in the treatment of covid-19
publisher	Brac University
publishDate	2024
url	http://hdl.handle.net/10361/22829
work_keys_str_mv	AT mondolwinifredclaire exploringthepotentialoforganicmoleculesinthetreatmentofcovid19
_version_	1814308269268664320

Exploring the potential of organic molecules in the treatment of covid-19

Similar Items