A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Language: | English |
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Brac University
2024
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| Online Access: | http://hdl.handle.net/10361/22683 |
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10361-22683 |
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10361-226832024-05-08T04:01:04Z A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine Shehab, Habibul Mohsin Yasmin, Hasina School of Pharmacy, Brac University Pharmacovigilance Rivastigmine Alzheimer's disease Dementia Pharmacoepidemiology. Mortality. Alzheimer's disease. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 40-43). The study employed the Food and Drug Administration Adverse Event Reporting System (FAERS) database to study the impact of Rivastigmine, an acetylcholinesterase inhibitor (AChI), on patient mortality. The study determines the mortality cases associated with rivastigmine, utilizing both the entire database and exclusively the AChI class as reference groups, stratified by gender. The results show a significant correlation between rivastigmine and patient mortality, with a greater number of deaths when compared to other medications in the class (ROR = 11.11; 95% CI = 7.40 – 16.70). Even when looking at the entire database, rivastigmine was still associated with a higher risk of mortality, and this was most pronounced for female patients (ROR = 4.47; 95% CI = 3.94 – 5.06). For male patients, however, the ROR = 9.67; (95% CI = 6.12 – 15.29) when comparing within the class, ROR = 2.65 (95% CI = 2.28 – 3.10) when comparing with the full database. Habibul Mohsin Shehab B. Pharmacy 2024-04-28T05:54:31Z 2024-04-28T05:54:31Z ©2023 2023-10 Thesis ID 19146009 http://hdl.handle.net/10361/22683 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 54 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Pharmacovigilance Rivastigmine Alzheimer's disease Dementia Pharmacoepidemiology. Mortality. Alzheimer's disease. |
| spellingShingle |
Pharmacovigilance Rivastigmine Alzheimer's disease Dementia Pharmacoepidemiology. Mortality. Alzheimer's disease. Shehab, Habibul Mohsin A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Shehab, Habibul Mohsin |
| format |
Thesis |
| author |
Shehab, Habibul Mohsin |
| author_sort |
Shehab, Habibul Mohsin |
| title |
A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| title_short |
A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| title_full |
A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| title_fullStr |
A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| title_full_unstemmed |
A pharmacovigilance study to determine risk of mortality in male and female patients with Alzheimer's disease using Rivastigmine |
| title_sort |
pharmacovigilance study to determine risk of mortality in male and female patients with alzheimer's disease using rivastigmine |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22683 |
| work_keys_str_mv |
AT shehabhabibulmohsin apharmacovigilancestudytodetermineriskofmortalityinmaleandfemalepatientswithalzheimersdiseaseusingrivastigmine AT shehabhabibulmohsin pharmacovigilancestudytodetermineriskofmortalityinmaleandfemalepatientswithalzheimersdiseaseusingrivastigmine |
| _version_ |
1814307221031354368 |