Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| Hizkuntza: | English |
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Brac University
2024
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| Sarrera elektronikoa: | http://hdl.handle.net/10361/22662 |
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10361-22662 |
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10361-226622024-04-24T21:02:00Z Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics Chowdhury, Saadia Shams Chowdhury, Namara Mariam School of Pharmacy, Brac University Domperidone Solubility Solid self-emulsifying drug delivery system (SSEDDS) Bioavailability Dissolution BCS Class II drug Drug carriers (Pharmacy) This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 29-35). The aim of this study was to use a solid-self emulsifying drug delivery system (S-SEDDS) to increase the solubility and dissolution rate of Domperidone (DMP), a poorly soluble, weakly basic anti-emetic medication. Several ratios of Kollisolv, Kolliphor® P188, and Glycerin were trialed and an S-SEDDS-DMP was formulated using the optimized ratio. Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRPD), Fourier-transform infrared spectroscopy (FT-IR), and in-vitro dissolution rate experiments were used to characterize the S-SEDDS-DMP. The lack of incompatibilities between DMP and the utilized polymers was established by FT-IR and DSC tests. DSC, SEM, and XRPD analyses demonstrated that the drug in the produced S-SEDDS changed from crystalline to amorphous. It may be stated that the S-SEDDS approach was a successful tool for improving DMP dissolution. Saadia Shams Chowdhury B. Pharmacy 2024-04-24T05:04:34Z 2024-04-24T05:04:34Z 2022 2022-09 Thesis ID: 18346063 http://hdl.handle.net/10361/22662 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 35 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Domperidone Solubility Solid self-emulsifying drug delivery system (SSEDDS) Bioavailability Dissolution BCS Class II drug Drug carriers (Pharmacy) |
| spellingShingle |
Domperidone Solubility Solid self-emulsifying drug delivery system (SSEDDS) Bioavailability Dissolution BCS Class II drug Drug carriers (Pharmacy) Chowdhury, Saadia Shams Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Chowdhury, Namara Mariam |
| author_facet |
Chowdhury, Namara Mariam Chowdhury, Saadia Shams |
| format |
Thesis |
| author |
Chowdhury, Saadia Shams |
| author_sort |
Chowdhury, Saadia Shams |
| title |
Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| title_short |
Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| title_full |
Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| title_fullStr |
Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| title_full_unstemmed |
Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| title_sort |
solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22662 |
| work_keys_str_mv |
AT chowdhurysaadiashams solidselfemulsifyingdrugdeliverysystemofdomperidoneforimprovedbiopharmaceuticalcharacteristics |
| _version_ |
1814307891957465088 |