A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Формат: | Дисертація |
| Мова: | English |
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Brac University
2024
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| Онлайн доступ: | http://hdl.handle.net/10361/22256 |
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10361-22256 |
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10361-222562024-01-30T21:02:40Z A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies Khan, MD Salehin Momtaz, Tanisha School of Pharmacy, Brac University Proliferation Cannabinoid Endocannabinoid system Apoptosis JNK and p38 MAPK pathway Ceramide Autophagy Cancer--Treatment This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 24-29). Cancer is a genetic disorder that causes uncontrolled cell proliferation and the cells are unable to maintain apoptosis which leads the cells to cross their natural boundaries. Treatment of this diseases requires a complex system of medicines for this purpose endocannabinoid system serves as a potential target for effective medicine development. Endocannabinoid system is homeostasis system present in mammalians. It comprises of endogenous and exogenous ligands, membrane bound receptors and degrading enzymes. The ligands of this system can be an effective molecule for drug development. Cannabinoid molecule can cause apoptosis in cancer cell through three different pathways they include JNK and p38 MAPK activation pathway, ceramide generating pathway and autophagy pathway. By modulating these pathways cannabinoid can be effective against various types of cancer cells. These molecules also have anti-inflammatory and analgesic properties and evidence shows that these properties can be useful in palliative care treatment with less side effects. MD Salehin Khan B. Pharmacy 2024-01-30T06:26:50Z 2024-01-30T06:26:50Z 2023 2023-02 Thesis ID 19146013 http://hdl.handle.net/10361/22256 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 30 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Proliferation Cannabinoid Endocannabinoid system Apoptosis JNK and p38 MAPK pathway Ceramide Autophagy Cancer--Treatment |
| spellingShingle |
Proliferation Cannabinoid Endocannabinoid system Apoptosis JNK and p38 MAPK pathway Ceramide Autophagy Cancer--Treatment Khan, MD Salehin A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Momtaz, Tanisha |
| author_facet |
Momtaz, Tanisha Khan, MD Salehin |
| format |
Thesis |
| author |
Khan, MD Salehin |
| author_sort |
Khan, MD Salehin |
| title |
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| title_short |
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| title_full |
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| title_fullStr |
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| title_full_unstemmed |
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| title_sort |
review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22256 |
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AT khanmdsalehin areviewofendocannabinoidsystemanditspharmacologicalroleasadrugtargetforcancertherapies AT khanmdsalehin reviewofendocannabinoidsystemanditspharmacologicalroleasadrugtargetforcancertherapies |
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1814309449768108032 |