A review of Cell-penetrating peptide mediated drug delivery to the brain
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Ձևաչափ: | Թեզիս |
| Լեզու: | English |
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Brac University
2024
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| Առցանց հասանելիություն: | http://hdl.handle.net/10361/22199 |
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10361-22199 |
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10361-221992024-01-28T21:03:22Z A review of Cell-penetrating peptide mediated drug delivery to the brain Tisha, Zarin Tasnim Sharmin, Sabrina School of Pharmacy, Brac University Cell-penetrating peptides Central nervous system Neurodegenerative diseases Blood-brain barrier Cytotoxicity This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 33-41). The central nervous system (CNS) is prone to different CNS disorders such as stroke, tumor, different neurodegenerative diseases such as Parkinson’s, Alzheimer’s disease, Huntington’s diseases etc. There are several treatment strategies available such as surgery, radiotherapy, chemotherapy, chemotherapeutic drugs etc. But the physiological barrier of CNS, the blood- brain barrier (BBB) poses as a main hindrance in these treatments. In this regard, cell- penetrating peptides (CPPs) mediated approach can be a promising treatment strategy to deliver the drug to brain crossing the BBB. CPPs are small peptides containing positive charge, can cross the cellular membrane and translocate different cargos containing protein, peptides, nucleic acids. They also have proven their ability to cross the BBB and deliver the cargos for efficient neural drug administration. They have less side effects and cytotoxcity. In this review, the main objective is to explore the potentiality of CPPs in delivering the drug to CNS for CNS disorders. B. Pharmacy 2024-01-28T04:05:54Z 2024-01-28T04:05:54Z 2023-02 Thesis ID 19146088 http://hdl.handle.net/10361/22199 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 41 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cell-penetrating peptides Central nervous system Neurodegenerative diseases Blood-brain barrier Cytotoxicity |
| spellingShingle |
Cell-penetrating peptides Central nervous system Neurodegenerative diseases Blood-brain barrier Cytotoxicity Tisha, Zarin Tasnim A review of Cell-penetrating peptide mediated drug delivery to the brain |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Sharmin, Sabrina |
| author_facet |
Sharmin, Sabrina Tisha, Zarin Tasnim |
| format |
Thesis |
| author |
Tisha, Zarin Tasnim |
| author_sort |
Tisha, Zarin Tasnim |
| title |
A review of Cell-penetrating peptide mediated drug delivery to the brain |
| title_short |
A review of Cell-penetrating peptide mediated drug delivery to the brain |
| title_full |
A review of Cell-penetrating peptide mediated drug delivery to the brain |
| title_fullStr |
A review of Cell-penetrating peptide mediated drug delivery to the brain |
| title_full_unstemmed |
A review of Cell-penetrating peptide mediated drug delivery to the brain |
| title_sort |
review of cell-penetrating peptide mediated drug delivery to the brain |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22199 |
| work_keys_str_mv |
AT tishazarintasnim areviewofcellpenetratingpeptidemediateddrugdeliverytothebrain AT tishazarintasnim reviewofcellpenetratingpeptidemediateddrugdeliverytothebrain |
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1814307153866915840 |