TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Accès en ligne: | http://hdl.handle.net/10361/22075 |
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10361-220752024-01-09T21:02:51Z TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study Afroza, Halima Talukder, Mesbah School of Pharmacy, Brac University Psoriasis Alopecia TNF-α inhibitor FAERS ROR Disproportionality analysis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 21-25). The objective of this study was to investigate the association between TNF-alpha inhibitors and alopecia cases in psoriasis patients reported in the Food and Drug Administration Adverse Event Reporting System (FAERS) database. We performed a disproportionality analysis (case/non-case method) to examine the relationship between the development of alopecia by the use of TNF-alpha inhibitors from January 2016 to September 2022. Cases were all alopecia reports, whereas non-cases were all the other reports reported throughout the research period. We calculated the reported odds ratio (ROR) and corresponding 95% confidence interval (CI) to assess disproportionality signals and determine the relationship between alopecia and TNF-alpha inhibitors. As a positive control, docetaxel was used. Our study found that only infliximab and certolizumab pegol showed signal for alopecia. Additional study into alopecia connected with TNF-alpha inhibitors usage in psoriasis patients is required as disproportionality signals may have been altered by stimulated reporting or nocebo effect. Halima Afroza B. Pharmacy 2024-01-09T04:08:56Z 2024-01-09T04:08:56Z 2023 2023-02 Thesis ID 19146018 http://hdl.handle.net/10361/22075 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 25 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Psoriasis Alopecia TNF-α inhibitor FAERS ROR Disproportionality analysis |
| spellingShingle |
Psoriasis Alopecia TNF-α inhibitor FAERS ROR Disproportionality analysis Afroza, Halima TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Talukder, Mesbah |
| author_facet |
Talukder, Mesbah Afroza, Halima |
| format |
Thesis |
| author |
Afroza, Halima |
| author_sort |
Afroza, Halima |
| title |
TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| title_short |
TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| title_full |
TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| title_fullStr |
TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| title_full_unstemmed |
TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| title_sort |
tnf-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22075 |
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AT afrozahalima tnfainhibitorinducedalopeciainpsoriaticdiseasepatientsapharmacovigilancestudy |
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