Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Acceso en liña: | http://hdl.handle.net/10361/22048 |
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10361-220482024-01-02T21:02:39Z Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study Mahee, Sadique Abdal Yasmin, Hasina School of Pharmacy, Brac University Alzheimer's disease Dementia Rivastigmine Death Rhabdomyolysis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 33-36). The following study utilized the Food and Drug Administration Adverse Event Reporting System (FAERS) database to determine the AChI inhibitor, rivastigmine’s effect on patient mortality as well as its side effect of rhabdomyolysis. The statistical analysis involved finding the number of cases of death/rhabdomyolysis for rivastigmine (using both the whole database and only the AChI class as comparators). The reporting odds ratios (ROR) was then calculated. In terms of patient mortality, the results showed that rivastigmine was significantly associated with more cases of deaths both when compared within the class (ROR = 10.62; CI 95% = 7.84 – 14.38; P < 0.0001) and also with the whole database (ROR = 5.90; CI 95% = 5.43 – 6.41; P < 0.0001). Additionally, no cases of reported rhabdomyolysis were found for rivastigmine. Hence, rivastigmine's apparent negative effect on patient mortality should be something to consider while selecting the drug for therapy. Sadique Abdal Mahee B. Pharmacy 2024-01-02T05:38:39Z 2024-01-02T05:38:39Z 2023 2023-02 Thesis ID 19146027 http://hdl.handle.net/10361/22048 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 36 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Alzheimer's disease Dementia Rivastigmine Death Rhabdomyolysis |
| spellingShingle |
Alzheimer's disease Dementia Rivastigmine Death Rhabdomyolysis Mahee, Sadique Abdal Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Mahee, Sadique Abdal |
| format |
Thesis |
| author |
Mahee, Sadique Abdal |
| author_sort |
Mahee, Sadique Abdal |
| title |
Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| title_short |
Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| title_full |
Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| title_fullStr |
Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| title_full_unstemmed |
Signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| title_sort |
signal detection of rhabdomyolysis and death for rivastigmine: a pharmacovigilance study |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22048 |
| work_keys_str_mv |
AT maheesadiqueabdal signaldetectionofrhabdomyolysisanddeathforrivastigmineapharmacovigilancestudy |
| _version_ |
1814309230139670528 |