Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023.
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| Materyal Türü: | Tez |
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Brac University
2023
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| Online Erişim: | http://hdl.handle.net/10361/21972 |
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10361-219722023-12-13T21:02:31Z Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh Afzal, Ahmed Rafi Afzal, Ahmed Rafi Department of Mathematics and Natural Sciences, Brac University Antibiotic resistance profile Vibrio cholerae MDR. Bacterial infections Public health Cholera Vibrio infections Multidrug resistance This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023. Catalogued from PDF version of thesis. Includes bibliographical references (pages 28-31). Antibiotic resistance is a growing global concern, posing significant challenges in the treatment of bacterial infections. Vibrio cholerae, a gram-negative bacterium responsible for the severe diarrheal disease cholera, has exhibited multidrug resistance, limiting the effectiveness of available treatment options. This study aimed to investigate the antibiotic resistance profile of Vibrio cholerae strains which were collected from each month between January-September from the year 2022 including isolates associated with a small outbreak occurring in April, 2022. All the strains (n=30) used in this study were Vibrio cholerae serogroup O1 and El Tor biotype. The antimicrobial susceptibility tests confirmed that all the test isolated strains were sensitive to Fluoroquinolone, Cephalosporin and Macrolides classes of antibiotics. But alarmingly, there were resistance to Imipenem (IPM), Trimethoprim sulfamethoxazole (SXT), Ampicillin (AMP) and Amoxicillin-clavulanic acid (AMC) with 83% of the strains being multidrug resistant (MDR). The isolated Vibrio cholerae strains showed the most significant resistance to AMP and SXT. Antibiotic resistance trend was found to correlate to the prevalence pattern of serotypes, while 94% of the Ogawa serotype was resistant to IPM whereas only 64% of the Inaba strains were resistant to that. The findings from this study will contribute to better treatment strategies for cholera patients, considering the antibiotic resistance profile of Vibrio cholerae strains. Ahmed Rafi Afzal B. Microbiology 2023-12-13T04:19:16Z 2023-12-13T04:19:16Z 2023 2023-06 Thesis ID 18226006 http://hdl.handle.net/10361/21972 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 31 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antibiotic resistance profile Vibrio cholerae MDR. Bacterial infections Public health Cholera Vibrio infections Multidrug resistance |
| spellingShingle |
Antibiotic resistance profile Vibrio cholerae MDR. Bacterial infections Public health Cholera Vibrio infections Multidrug resistance Afzal, Ahmed Rafi Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023. |
| author2 |
Afzal, Ahmed Rafi |
| author_facet |
Afzal, Ahmed Rafi Afzal, Ahmed Rafi |
| format |
Thesis |
| author |
Afzal, Ahmed Rafi |
| author_sort |
Afzal, Ahmed Rafi |
| title |
Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| title_short |
Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| title_full |
Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| title_fullStr |
Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| title_full_unstemmed |
Trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in Bangladesh |
| title_sort |
trends of multidrug resistance phenotypes in vibrio cholerae causing cholera in bangladesh |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/21972 |
| work_keys_str_mv |
AT afzalahmedrafi trendsofmultidrugresistancephenotypesinvibriocholeraecausingcholerainbangladesh |
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1814308913966743552 |