Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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Brac University
2023
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| Accès en ligne: | http://hdl.handle.net/10361/21971 |
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10361-219712023-12-12T21:02:42Z Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review Mondal, Shawon Chowdhury, Namara Mariam School of Pharmacy, Brac University Colorectal cancer Oxidative damage In vivo In vitro Metastatic tumor This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 30-35). Repurposing drugs may be the answer to overcoming these challenges associated with cancer treatment. Albendazole (ABZ) and Mebendazole (MBZ), which are often used to treat helminthic infections, have demonstrated significant promise as cancer treatments. However, neither their clinical importance nor their obvious mechanism in CRC treatment have been thoroughly examined. To learn more about these mechanisms and their clinical relevance, researchers have looked at the regulation of apoptosis in the human CRC cell lines HCT-15, HCT-116, HT-29, and SW480, selective apoptotic cell death in CRC adenocarcinoma cells in their G2/M phase, and DNA fragmentation mechanism through oxidative damage to CT-DNA by ABZ. The literature highlighting the potential anticancer mechanisms of MBZ, the inhibitory mechanism of tubulin polymer in CRC cell line, the inhibition of angiogenesis in exiting metastatic tumor, and the induction of the immune system via proinflammatory(M1) mediation and DYRK1B kinase modulation are also summarized in this review. To establish clinical relevance and highlight the therapeutic efficacy of ABZ and MBZ, this review also reviews the pertinent literature and clinical trials, in vivo, and in vitro investigations that are currently accessible. Shawon Mondal B. Pharmacy 2023-12-12T09:04:46Z 2023-12-12T09:04:46Z 2022 2022-10 Thesis ID 19146068 http://hdl.handle.net/10361/21971 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 35 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Colorectal cancer Oxidative damage In vivo In vitro Metastatic tumor |
| spellingShingle |
Colorectal cancer Oxidative damage In vivo In vitro Metastatic tumor Mondal, Shawon Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Chowdhury, Namara Mariam |
| author_facet |
Chowdhury, Namara Mariam Mondal, Shawon |
| format |
Thesis |
| author |
Mondal, Shawon |
| author_sort |
Mondal, Shawon |
| title |
Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| title_short |
Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| title_full |
Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| title_fullStr |
Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| title_full_unstemmed |
Repurposing Albendazole and Mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| title_sort |
repurposing albendazole and mebendazole, an antiparasitic drug in treating colorectal cancer- a review |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/21971 |
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AT mondalshawon repurposingalbendazoleandmebendazoleanantiparasiticdrugintreatingcolorectalcancerareview |
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