A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2023
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| Acceso en liña: | http://hdl.handle.net/10361/21969 |
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10361-219692023-12-12T21:02:40Z A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death Jahan, Nusrat Yasmin, Hasina School of Pharmacy, Brac University Alzheimer’s disease Dementia Donepezil Mortality benefit Rhabdomyolysis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 43-47). Alzheimer’s disease is an age-related neurodegenerative disease that effects the cognitive ability of a person. The cholinesterase inhibitor “donepezil” is used to treat Alzheimer's disease. Donepezil has shown the greatest advantages for improving patient’s lifestyles and cognitive abilities. The goal of this research is to offer a precise statistical analysis of the mortality benefit and rhabdomyolysis ratio in AD patients using the drug donepezil. The FAERS database was utilized to gather information on adverse events that were reported, and ROR was used as a statistical method to determine the mortality and rhabdomyolysis ratio in patients using donepezil. According to our research, donepezil has a positive impact on patient mortality than other cholinesterase inhibitors. On the other hand, in comparison to other cholinesterase inhibitors, donepezil also showed a relatively higher incidence of rhabdomyolysis cases. It has been discovered that donepezil increases patient’s life expectancy, but it has some limitations. Nusrat Jahan B. Pharmacy 2023-12-12T06:38:43Z 2023-12-12T06:38:43Z 2023 2023-02 Thesis ID 19146001 http://hdl.handle.net/10361/21969 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 47 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Alzheimer’s disease Dementia Donepezil Mortality benefit Rhabdomyolysis |
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Alzheimer’s disease Dementia Donepezil Mortality benefit Rhabdomyolysis Jahan, Nusrat A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Jahan, Nusrat |
| format |
Thesis |
| author |
Jahan, Nusrat |
| author_sort |
Jahan, Nusrat |
| title |
A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| title_short |
A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| title_full |
A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| title_fullStr |
A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| title_full_unstemmed |
A pharmacovigilance study on Donepezil: signal detection of rhabdomyolysis and death |
| title_sort |
pharmacovigilance study on donepezil: signal detection of rhabdomyolysis and death |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/21969 |
| work_keys_str_mv |
AT jahannusrat apharmacovigilancestudyondonepezilsignaldetectionofrhabdomyolysisanddeath AT jahannusrat pharmacovigilancestudyondonepezilsignaldetectionofrhabdomyolysisanddeath |
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1814307152853991424 |