Barriers to oral and inhaled drug delivery: a review
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
| מחבר ראשי: | |
|---|---|
| מחברים אחרים: | |
| פורמט: | Thesis |
| שפה: | English |
| יצא לאור: |
Brac University
2023
|
| נושאים: | |
| גישה מקוונת: | http://hdl.handle.net/10361/21246 |
| id |
10361-21246 |
|---|---|
| record_format |
dspace |
| spelling |
10361-212462023-09-25T21:06:42Z Barriers to oral and inhaled drug delivery: a review Kamal, Farhana Sheikh, Zara Department of Pharmacy, Brac University Oral Pulmonary Drugs Delivery Routes Barriers Medical policy Drug delivery systems This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 24-33). Oral and pulmonary routes of drug administration are the two most common modes to deliver drugs to patients owing to their non-invasive nature. Among the two, the oral route is still the most preferred one due to a number of advantages such as ease of administration without requiring any assistance that offers enhanced patient compliance and cost-effectiveness. Several factors affect absorption orally delivered drugs including drug solubility, permeability across the mucosa, and stable position in the gastrointestinal tract environment. It is fundamental to understand the physicochemical, biochemical, metabolic and biological barriers which limit the overall bioavailability of therapeutic agents to address the problems associated with decreased oral absorption and bioavailability. Pulmonary route of drug administration holds the potential to overcome these problems of reduced absorption associated with oral drug delivery. However, pulmonary drug delivery is also negatively affected by mechanical, chemical, immunological barriers along with behavioral barriers linked with use of inhaler devices and poor patient adherence. To this end, the present review discusses the barriers associated with oral and pulmonary drug delivery, along with highlights of the advantages and disadvantages of both routes of drug administration with future perspectives. Farhana Kamal B. Pharmacy 2023-09-25T07:47:28Z 2023-09-25T07:47:28Z 2022 2022-08 Thesis ID 18146078 http://hdl.handle.net/10361/21246 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 43 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Oral Pulmonary Drugs Delivery Routes Barriers Medical policy Drug delivery systems |
| spellingShingle |
Oral Pulmonary Drugs Delivery Routes Barriers Medical policy Drug delivery systems Kamal, Farhana Barriers to oral and inhaled drug delivery: a review |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Sheikh, Zara |
| author_facet |
Sheikh, Zara Kamal, Farhana |
| format |
Thesis |
| author |
Kamal, Farhana |
| author_sort |
Kamal, Farhana |
| title |
Barriers to oral and inhaled drug delivery: a review |
| title_short |
Barriers to oral and inhaled drug delivery: a review |
| title_full |
Barriers to oral and inhaled drug delivery: a review |
| title_fullStr |
Barriers to oral and inhaled drug delivery: a review |
| title_full_unstemmed |
Barriers to oral and inhaled drug delivery: a review |
| title_sort |
barriers to oral and inhaled drug delivery: a review |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/21246 |
| work_keys_str_mv |
AT kamalfarhana barrierstooralandinhaleddrugdeliveryareview |
| _version_ |
1814306845110566912 |