A review on dissolving microneedle mediated transdermal insulin delivery
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
| Hoofdauteur: | |
|---|---|
| Andere auteurs: | |
| Formaat: | Thesis |
| Taal: | English |
| Gepubliceerd in: |
Brac University
2023
|
| Onderwerpen: | |
| Online toegang: | http://hdl.handle.net/10361/19388 |
| id |
10361-19388 |
|---|---|
| record_format |
dspace |
| spelling |
10361-193882023-08-13T21:02:09Z A review on dissolving microneedle mediated transdermal insulin delivery Akter, Khadija Uddin, Dr. Md Jasim Department of Pharmacy, Brac University Microneedle Transdermal Insulin Diabetes mellitus Hypodermic Transdermal medication Drug delivery systems This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis. Includes bibliographical references (pages 33-37). Microneedles (MNs) are microscopic applicators used to deliver vaccines or other drugs across various barriers. Whereas the most favorite use of MN is transdermal applications. Generally, four types of MN are present. These are solid MNs, hollow MNs, coated MNs and dissolvable MNs. They can deliver drugs through different mechanisms. The vision of this report was to create a dissolving MNs application system. By which way insulin loaded dissolving MNs were made on a chip. By this lesson we can gain optimal relative bioavailability for insulin delivery using a gelatin/CMC MNs patch in comparison with traditional hypodermic injection. It may be a satisfactory delivery device for those drugs which are employed for diabetes and these drugs are not permeable. By insertion tests on human cadaveric skin it is indicated that dissolving MNs could deal as proficient devices for transdermal drug delivery in medical use. Also, to get total absorption of insulin, two-layered dissolving MNs array chips were equipped and delivered to the abdominal skin of rats. Glucose levels of plasma were calculated for 6h. The relative pharmacological availability was determined by comparing the hypoglycemic effect which was attained after subcutaneous injection. Khadija Akter B. Pharmacy 2023-08-13T09:46:36Z 2023-08-13T09:46:36Z 2021 2021-05 Thesis ID: 16346052 http://hdl.handle.net/10361/19388 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 37 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Microneedle Transdermal Insulin Diabetes mellitus Hypodermic Transdermal medication Drug delivery systems |
| spellingShingle |
Microneedle Transdermal Insulin Diabetes mellitus Hypodermic Transdermal medication Drug delivery systems Akter, Khadija A review on dissolving microneedle mediated transdermal insulin delivery |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. |
| author2 |
Uddin, Dr. Md Jasim |
| author_facet |
Uddin, Dr. Md Jasim Akter, Khadija |
| format |
Thesis |
| author |
Akter, Khadija |
| author_sort |
Akter, Khadija |
| title |
A review on dissolving microneedle mediated transdermal insulin delivery |
| title_short |
A review on dissolving microneedle mediated transdermal insulin delivery |
| title_full |
A review on dissolving microneedle mediated transdermal insulin delivery |
| title_fullStr |
A review on dissolving microneedle mediated transdermal insulin delivery |
| title_full_unstemmed |
A review on dissolving microneedle mediated transdermal insulin delivery |
| title_sort |
review on dissolving microneedle mediated transdermal insulin delivery |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19388 |
| work_keys_str_mv |
AT akterkhadija areviewondissolvingmicroneedlemediatedtransdermalinsulindelivery AT akterkhadija reviewondissolvingmicroneedlemediatedtransdermalinsulindelivery |
| _version_ |
1814306882740813824 |