Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023.
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Brac University
2023
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| 在线阅读: | http://hdl.handle.net/10361/19365 |
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10361-193652023-08-08T21:02:20Z Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity Nath Tonmoy, Joy Deb Turjya, Rafeed Rahman Department of Mathematics and Natural Sciences, Brac University Pan-genome analysis Alistipes Antimicrobial resistance Virulence gene Toxin-antitoxin system Secretion system of Alistipes species. Bacterial genomes. Microbial genomes--Laboratory manuals. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023. Catalogued from PDF version of thesis. Includes bibliographical references (pages 84-90). Alistipes, a recently identified and comparatively unexplored bacterial genus of the Bacteroidetes phylum, has several species isolated from both healthy and diseased individuals. This gram negative, anaerobic, rod-shaped genus of bacteria has multiple complete genomes of different species available; yet the pathogenicity and other clinically significant genomic characteristics have not been characterized. In this study, 16 genomes of different Alistipes species were used for pan-genome analysis to understand the diversity of the genes across the genus. Furthermore, the same genomes were used to identify the genes related to antimicrobial resistance, virulence, and other clinically significant genomic characteristics. In this comparative genomic analysis, the conserved characteristics as well as the variability of different species of Alistipes have been elucidated. Thirty-six antibiotic resistance genes that provide different strains and/or isolates of Alistipes resistance to antibiotics e.g., rifampicin, fluoroquinolone, tetracycline, etc. were identified. Additionally, the identification of bacterial type II secretion system and type II toxin antitoxin systems as well as other virulence genes in the Alistipes genomes provides new insights on the impact of the bacteria on human health. Ultimately, the identification of pathogenicity associated factors may lead to accurate therapeutic interventions when dealing with different Alistipes species. Joy Deb Nath Tonmoy B. Microbiology 2023-08-08T10:00:50Z 2023-08-08T10:00:50Z 2023 2023-01 Thesis ID: 17126033 http://hdl.handle.net/10361/19365 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 90 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Pan-genome analysis Alistipes Antimicrobial resistance Virulence gene Toxin-antitoxin system Secretion system of Alistipes species. Bacterial genomes. Microbial genomes--Laboratory manuals. |
| spellingShingle |
Pan-genome analysis Alistipes Antimicrobial resistance Virulence gene Toxin-antitoxin system Secretion system of Alistipes species. Bacterial genomes. Microbial genomes--Laboratory manuals. Nath Tonmoy, Joy Deb Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Microbiology, 2023. |
| author2 |
Turjya, Rafeed Rahman |
| author_facet |
Turjya, Rafeed Rahman Nath Tonmoy, Joy Deb |
| format |
Thesis |
| author |
Nath Tonmoy, Joy Deb |
| author_sort |
Nath Tonmoy, Joy Deb |
| title |
Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| title_short |
Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| title_full |
Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| title_fullStr |
Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| title_full_unstemmed |
Pan-genome analysis of Alistipes Genomes: Exploration of diversity and pathogenicity |
| title_sort |
pan-genome analysis of alistipes genomes: exploration of diversity and pathogenicity |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19365 |
| work_keys_str_mv |
AT nathtonmoyjoydeb pangenomeanalysisofalistipesgenomesexplorationofdiversityandpathogenicity |
| _version_ |
1814309217686781952 |