Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| Langue: | English |
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Brac University
2023
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| Accès en ligne: | http://hdl.handle.net/10361/19281 |
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10361-19281 |
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10361-192812023-08-03T21:02:01Z Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole Ahmed, Alifa Kabir, Dr. Eva Rahman Department of Pharmacy, Brac University Self-Micro Emulsifying Drug Delivery System (SMEDDS) Bioavailability Dissolution BCS Class II drug Itraconazole Drug carriers (Pharmacy) This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 26-29). The study is designed to improve the bioavailability of Itraconazole by developing a self-micro emulsifying drug delivery system (SMEDDS). A series of SMEDDS were prepared with different ratios of oil, surfactant and co-surfactant and examined for emulsification. Pseudo ternary phase diagram was used to find out the optimized concentration of the components. The dissolution profile of the optimized SMEDDS-ITZ was performed in aqueous media. The physicochemical characteristic of SMEDDS-ITZ were also examined by dynamic light scattering (DLS). The possible interaction between the components were checked by Fourier Transform Infrared spectroscopy (FT-IR). The results from the dissolution study of the prepared formulation suggests that the SMEDDS can be promising approach for Itraconazole and other Biopharmaceutics Classification System (BCS) Class II drugs to reduce dosing frequency and to improve the bioavailability. Alifa Ahmed B. Pharmacy 2023-08-03T09:49:10Z 2023-08-03T09:49:10Z 2022 2022-09 Thesis ID: 18346002 http://hdl.handle.net/10361/19281 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 29 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Self-Micro Emulsifying Drug Delivery System (SMEDDS) Bioavailability Dissolution BCS Class II drug Itraconazole Drug carriers (Pharmacy) |
| spellingShingle |
Self-Micro Emulsifying Drug Delivery System (SMEDDS) Bioavailability Dissolution BCS Class II drug Itraconazole Drug carriers (Pharmacy) Ahmed, Alifa Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Kabir, Dr. Eva Rahman |
| author_facet |
Kabir, Dr. Eva Rahman Ahmed, Alifa |
| format |
Thesis |
| author |
Ahmed, Alifa |
| author_sort |
Ahmed, Alifa |
| title |
Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| title_short |
Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| title_full |
Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| title_fullStr |
Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| title_full_unstemmed |
Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole |
| title_sort |
self-micro emulsifying drug delivery system: an approach to improve the solubility of itraconazole |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19281 |
| work_keys_str_mv |
AT ahmedalifa selfmicroemulsifyingdrugdeliverysystemanapproachtoimprovethesolubilityofitraconazole |
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1814308482666463232 |