Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023.
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Brac University
2023
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| 在线阅读: | http://hdl.handle.net/10361/19152 |
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10361-191522023-07-30T21:02:06Z Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population Ahmed, Nafisa Hossain, Mohammed Mahboob Kabir, Yearul Department of Mathematics and Natural Sciences, Brac University DNA repair genes Polymorphism XRCC1 XPD Prostate cancer Biomarker Prostate--Cancer. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023. Catalogued from PDF version of thesis. Includes bibliographical references (pages 43-46). This study examined the effects of the X-ray cross-complementing gene 1 (XRCC1) Arg194Trp and Xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms on the risk, severity, and clinical parameter of prostate cancer in Bangladeshi males. The blood samples and data of 132 prostate cancer patients and 135 healthy controls were obtained. PCR-RFLP was used to conduct a genotype analysis. Compared to the Arg/Arg genotype of XRCC1, the homozygous mutant Trp/Trp genotype was associated with prostate cancer with an Odd Ratio (OR) of 7.50 (95% CI, 1.227-85.12; p=0.04). In comparison to Arg/Arg + Arg/Trp genotypes, the Trp/Trp genotype increased risk by 7.5 folds (OR=7.50; 95% CI=1.23-85.12; p=0.04). XPD variants did not increase prostate cancer risk. Among prostate cancer patients, the XRCC1 Trp/Trp variant was associated with hematuria risk, higher mean serum creatinine, and mean prostate-specific antigen (PSA) levels. Only higher mean serum creatinine levels were associated with the XPD Gln/Gln variant. Tumor grade, tumor aggressiveness, prostate abnormalities, or UTIs were not affected by either XRCC1 or XPD variations (p>0.05). Nafisa Ahmed B. Biotechnology 2023-07-30T07:55:08Z 2023-07-30T07:55:08Z 2023 2023-02 Thesis ID 19136026 http://hdl.handle.net/10361/19152 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 46 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
DNA repair genes Polymorphism XRCC1 XPD Prostate cancer Biomarker Prostate--Cancer. |
| spellingShingle |
DNA repair genes Polymorphism XRCC1 XPD Prostate cancer Biomarker Prostate--Cancer. Ahmed, Nafisa Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023. |
| author2 |
Hossain, Mohammed Mahboob |
| author_facet |
Hossain, Mohammed Mahboob Ahmed, Nafisa |
| format |
Thesis |
| author |
Ahmed, Nafisa |
| author_sort |
Ahmed, Nafisa |
| title |
Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| title_short |
Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| title_full |
Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| title_fullStr |
Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| title_full_unstemmed |
Association of XRCC1 and XPD polymorphism with risk of prostate cancer in Bangladesh population |
| title_sort |
association of xrcc1 and xpd polymorphism with risk of prostate cancer in bangladesh population |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19152 |
| work_keys_str_mv |
AT ahmednafisa associationofxrcc1andxpdpolymorphismwithriskofprostatecancerinbangladeshpopulation |
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1814307497158115328 |