Development and characterization of mucoadhesive nanoparticles of albendazole
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| التنسيق: | أطروحة |
| اللغة: | English |
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Brac University
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10361/19138 |
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10361-19138 |
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10361-191382023-07-30T21:02:27Z Development and characterization of mucoadhesive nanoparticles of albendazole Islam, Ifti Ara Sayka Khan, Tanisha Tabassum Department of Pharmacy, Brac University Albendazole Dissolution Mucoadhesive Nanoparticles Polymers Pharmaceutical technology. Pharmacy. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 17-19). Albendazole is broad spectrum anthelmintic agent with poor aqueous solubility. It is usually available in the form of chewable tablets and often require administration in large doses to overcome the reduced therapeutic efficacy issue due to low solubility. High drug loading often leads to patient incompliance and side effects. The aim of this study was to develop a mucoadhesive nanoparticle formulation of Albendazole to improve its aqueous solubility as well as to prolong its duration of therapeutic activity at the target site. To prepare the mucoadhesive nanoparticles, hydrophilic polymers such as chitosan, sodium alginate and HPMC K4M were used. Dissolution study of the formulation was performed followed by its characterization. The dissolution profile showed 5.5 fold (81%) increase in the amount of drug released compared to crystalline Albendazole, indicating an increase in solubility. Furthermore, the physicochemical characterization demonstrated nano-size distribution of particles, enhanced surface area, advent of amorphous state and negligible interaction between Albendazole and polymers Ifti Ara Islam B. Pharmacy 2023-07-30T06:51:57Z 2023-07-30T06:51:57Z 2022 2022-09 Thesis ID: 18346015 http://hdl.handle.net/10361/19138 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 19 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Albendazole Dissolution Mucoadhesive Nanoparticles Polymers Pharmaceutical technology. Pharmacy. |
| spellingShingle |
Albendazole Dissolution Mucoadhesive Nanoparticles Polymers Pharmaceutical technology. Pharmacy. Islam, Ifti Ara Development and characterization of mucoadhesive nanoparticles of albendazole |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Sayka Khan, Tanisha Tabassum |
| author_facet |
Sayka Khan, Tanisha Tabassum Islam, Ifti Ara |
| format |
Thesis |
| author |
Islam, Ifti Ara |
| author_sort |
Islam, Ifti Ara |
| title |
Development and characterization of mucoadhesive nanoparticles of albendazole |
| title_short |
Development and characterization of mucoadhesive nanoparticles of albendazole |
| title_full |
Development and characterization of mucoadhesive nanoparticles of albendazole |
| title_fullStr |
Development and characterization of mucoadhesive nanoparticles of albendazole |
| title_full_unstemmed |
Development and characterization of mucoadhesive nanoparticles of albendazole |
| title_sort |
development and characterization of mucoadhesive nanoparticles of albendazole |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19138 |
| work_keys_str_mv |
AT islamiftiara developmentandcharacterizationofmucoadhesivenanoparticlesofalbendazole |
| _version_ |
1814308701031366656 |