Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city
This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023.
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Brac University
2023
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| גישה מקוונת: | http://hdl.handle.net/10361/19130 |
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10361-191302023-07-30T21:02:23Z Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city Tabassum, Nafisa Hossain, Mahboob Hossain, Muhammad Akram Department of Mathematics and Natural Sciences, Brac University RT-PCR HRCT Normal chest CT GGO GGO+CO CRP D-dimer PCT IL-6 Clinical manifestation Hematological parameters (TC, DC, Platelet) SpO2 COVID-19 (Disease) Immunology Biotechnology This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 70-76). The chest HRCT scan can be used as a diagnostic tool for COVID-19 disease in cases of clinical suspicion, false-negative RT-PCR, or unavailability of the test. The study aimed to investigate the relation of HRCT findings (1) Normal, (2) Ground Glass Opacity (GGO), and (3) GGO plus Consolidation (GGO+Co) with hematological, biochemical, immunological parameters, and clinical manifestations of COVID-19 patients. As such, oone hundred and thirty-five COVID-19 RT-PCR-confirmed patients were enrolled in this study from a dedicated COVID-19 ward in a tertiary care hospitals in Chattogram city. Chest HRCT scans were analyzed for all enrolled patients. D-dimer, CRP, procalcitonin, IL-6, and total count/TC, differential count/DC, and Platelet count were analyzed by automated biochemistry and hematology analyzer. Among the participants, 62.7% were male and 37.3% female with age for both genders were 49 years. Based on HRCT density, normal, GGO, and GGO+Co cases were identified in 36%, 21%, and 43% of the patients, respectively. Lung infections were not detected in the normal group but were present in the GGO and GGO+Co groups. Mild (75.86%), moderate (13.79%), and severe (10.34%) cases were found in the GGO,group, and they were 24.13%, 50%, and 24.13% respectively in GGO+Co groups. Critical cases (1.72%) were found only in the GGO+Co group. Clinical manifestations were recorded in three groups of COVID-19 patients where the fever was the most predominant symptom in the Normal (91.67%), GGO (92.85%), and GGO+Co (96.55%) groups, followed by cough in Normal (68.08%), GGO (71.42%), and GGO+Co (72.41%). In the Normal patients group, Mild, Moderate, and severe oxygen saturation (SpO2) levels in N=47(97.92%, N=1(2.08%), and N=0 (0%) respectively. SpO2 levels, Mild 93.10% (N=27), Moderate 6.89 %( N=2), and Severe 0 %(N=0) had detected in GGO patients groups. On the other hand, SpO2 level N=39/67.24% (Mild), N=1/1.72 %( Moderate), and only N=18/31.03 %( Severe) cases were found in GGO+Co patients groups. GGO+Co group had higher levels of CRP (82.37 mg/L), D-dimer (0.97 μg/ml), and PCT (0.68 ng/mL) compared to normal cases with CRP (13.22 mg/L), D-dimer(0.44 μg/ml), and PCT (0.14 ng/mL), and GGO cases had levels of CRP (25.88 mg/L), D-dimer (0.55 μg/ml), and PCT (0.22 ng/mL). Significant p-values (GGO+Co vs normal) were found for CRP (p=0.000000077*) and PCT (p=0.000000077*). Differences in hematological features were also observed, with higher counts neutrophils (72.45%), and platelets (231.92 x 10^9/L) in the GGO+Co group compared to the normal and GGO cases. Il-6 mean levels were 52.34pg/ML, 80.6 pg/ML, and 105.78 pg/ML for normal, GGO, and GGO+Co groups, respectively. In suspected COVID-19 RT-PCR false negative cases, chest HRCT can be used as an alternative test, and its laboratory findings (CRP, PCT, D-dimer, Total & differential Count of WBC, Platelet) can be taken as prognostic markers for the treatment of COVID-19 to reduce the mortality rate. Nafisa Tabassum M. Biotechnology 2023-07-30T05:47:14Z 2023-07-30T05:47:14Z 2023 2023-03 Thesis ID 16276002 http://hdl.handle.net/10361/19130 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 85 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
RT-PCR HRCT Normal chest CT GGO GGO+CO CRP D-dimer PCT IL-6 Clinical manifestation Hematological parameters (TC, DC, Platelet) SpO2 COVID-19 (Disease) Immunology Biotechnology |
| spellingShingle |
RT-PCR HRCT Normal chest CT GGO GGO+CO CRP D-dimer PCT IL-6 Clinical manifestation Hematological parameters (TC, DC, Platelet) SpO2 COVID-19 (Disease) Immunology Biotechnology Tabassum, Nafisa Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| description |
This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023. |
| author2 |
Hossain, Mahboob |
| author_facet |
Hossain, Mahboob Tabassum, Nafisa |
| format |
Thesis |
| author |
Tabassum, Nafisa |
| author_sort |
Tabassum, Nafisa |
| title |
Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| title_short |
Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| title_full |
Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| title_fullStr |
Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| title_full_unstemmed |
Relation of chest HRCT scan findings with hematological, biochemical, and immunological parameters of hospitalized Covid-19 patients in a tertiary hospital in Chattogram city |
| title_sort |
relation of chest hrct scan findings with hematological, biochemical, and immunological parameters of hospitalized covid-19 patients in a tertiary hospital in chattogram city |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19130 |
| work_keys_str_mv |
AT tabassumnafisa relationofchesthrctscanfindingswithhematologicalbiochemicalandimmunologicalparametersofhospitalizedcovid19patientsinatertiaryhospitalinchattogramcity |
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