Mutation in DNA polymerase γ: mitochondrial disorders
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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Brac University
2023
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| Online dostop: | http://hdl.handle.net/10361/19018 |
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10361-190182023-07-26T21:02:02Z Mutation in DNA polymerase γ: mitochondrial disorders Hossain, Sadman Sanjid Ashrafi, Sania Department of Pharmacy, Brac University Mitochondria DNA polymerase POLG DNA replication DNA repair Mitochondrial DNA This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 15-18). Together with key components of the mitochondrial DNA (mtDNA) replication machinery, DNA polymerase γ (POLG) replicates the human mitochondrial genome. Defects in mtDNA replication or nucleotide metabolism result in mtDNA deletions, point mutations, or depletion. The resulting loss of cellular respiration ultimately causes mitochondrial genetic diseases, such as mtDNA deletion disorders, progressive external ophthalmoplegia, ataxia- neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy, as well as mtDNA depletion syndromes like Alpers or early infantile hepatocerebral syndromes. This review paper provides an overview of the most recent research on the role of POLG in the manifestation of mitochondrial diseases. Sadman Sanjid Hossain B. Pharmacy 2023-07-26T06:01:25Z 2023-07-26T06:01:25Z 2022 2022 Thesis ID 18346040 http://hdl.handle.net/10361/19018 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 18 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Mitochondria DNA polymerase POLG DNA replication DNA repair Mitochondrial DNA |
| spellingShingle |
Mitochondria DNA polymerase POLG DNA replication DNA repair Mitochondrial DNA Hossain, Sadman Sanjid Mutation in DNA polymerase γ: mitochondrial disorders |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Ashrafi, Sania |
| author_facet |
Ashrafi, Sania Hossain, Sadman Sanjid |
| format |
Thesis |
| author |
Hossain, Sadman Sanjid |
| author_sort |
Hossain, Sadman Sanjid |
| title |
Mutation in DNA polymerase γ: mitochondrial disorders |
| title_short |
Mutation in DNA polymerase γ: mitochondrial disorders |
| title_full |
Mutation in DNA polymerase γ: mitochondrial disorders |
| title_fullStr |
Mutation in DNA polymerase γ: mitochondrial disorders |
| title_full_unstemmed |
Mutation in DNA polymerase γ: mitochondrial disorders |
| title_sort |
mutation in dna polymerase γ: mitochondrial disorders |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/19018 |
| work_keys_str_mv |
AT hossainsadmansanjid mutationindnapolymerasegmitochondrialdisorders |
| _version_ |
1814308828504653824 |