The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2022.

Manylion Llyfryddiaeth
Prif Awdur:	Belal, Progga Parmita
Awduron Eraill:	Hossain, M. Mahboob
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	Brac University 2023
Pynciau:	Levofloxacin Azithromycin Multidrug-resistant Acinetobacter baumannii Klebsiella pneumoniae Pseudomonas aeruginosa. Acinetobacter. Pseudomonas aeruginosa infections Drug resistance in microorganisms.
Mynediad Ar-lein:	http://hdl.handle.net/10361/18294

id	10361-18294
record_format	dspace
spelling	10361-182942023-05-15T21:01:58Z The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Belal, Progga Parmita Hossain, M. Mahboob Ahmed, Akash Department of Mathematics and Natural Sciences, Brac University Levofloxacin Azithromycin Multidrug-resistant Acinetobacter baumannii Klebsiella pneumoniae Pseudomonas aeruginosa. Acinetobacter. Pseudomonas aeruginosa infections Drug resistance in microorganisms. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2022. Catalogued from PDF version of thesis. Includes bibliographical references (pages 61-64). Pneumonia affects everyone, particularly young children under the age of five. Acinetobacter baumannii, Klebsiella pneumonia, and Pseudomonas aeruginosa are one of the main causes of pneumonia as they cause a wide range of diseases which includes lung infections (pneumonia), bloodstream infections, wound or urinary tract infections. A. baumannii has become a major public health threat because 63 percent of Acinetobacter strains are multidrug-resistant. The purpose of this study is to develop a viable method for battling infections brought about by multidrug-resistant Acinetobacter baumannii, Klebsiella pneumonia, and Pseudomonas aeruginosa in Bangladesh. From gathered bacterial samples, 10 out of 18 samples were multiple antibiotic resistant which was identified by performing an antibiogram utilizing 18 different antibiotics from 13 of various classes including Macrolides, Polymyxins, Tetracycline, Nitroimidazole, Cephalosporin, Beta-lactam, Quinolone, Fluoroquinolones, Aminoglycosides, and Penicillin. Then, primary screening of antibiotic susceptibility was done which categorized the pathogens into multidrug-resistant, extensively drug-resistant (XDR), and pan-drug-resistant (PDR). Next, by using the Minimum Inhibitory Concentration (MIC) method, individual antibiotics and a combination of screened antibiotics activity were measured. Afterward, the Fractional Inhibitory Concentration (FIC) index to provide statistical substantiation of results. The highest demonstrated MIC value for Levofloxacin was 400 μg/ml, while the lowest was 50 μg/ml. The highest value for Azithromycin was 400 μg/ml and the lowest was 100 μg/ml. For Acinetobacter baumannii, Klebsiella pneumonia, and Pseudomonas aeruginosa samples, a synergic effect was found in Levofloxacin in combination with azithromycin determined by FIC Index was below 0.5 suggesting the synergistic effect of their combination. The research result is very significant because by using a combination of antibiotics, the needed amount of antibiotics on resistant pathogens can be decreased. This study has far-reaching consequences for the future of combination therapy against multidrug-resistant bacteria. Progga Parmita Belal B. Biotechnology 2023-05-15T10:29:14Z 2023-05-15T10:29:14Z 2022 2022-11 Thesis ID: 17336013 http://hdl.handle.net/10361/18294 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 68 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	Levofloxacin Azithromycin Multidrug-resistant Acinetobacter baumannii Klebsiella pneumoniae Pseudomonas aeruginosa. Acinetobacter. Pseudomonas aeruginosa infections Drug resistance in microorganisms.
spellingShingle	Levofloxacin Azithromycin Multidrug-resistant Acinetobacter baumannii Klebsiella pneumoniae Pseudomonas aeruginosa. Acinetobacter. Pseudomonas aeruginosa infections Drug resistance in microorganisms. Belal, Progga Parmita The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
description	This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2022.
author2	Hossain, M. Mahboob
author_facet	Hossain, M. Mahboob Belal, Progga Parmita
format	Thesis
author	Belal, Progga Parmita
author_sort	Belal, Progga Parmita
title	The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
title_short	The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
title_full	The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
title_fullStr	The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
title_full_unstemmed	The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
title_sort	combined effect of levofloxacin and azithromycin against multidrug-resistant acinetobacter baumannii, klebsiella pneumoniae, and pseudomonas aeruginosa.
publisher	Brac University
publishDate	2023
url	http://hdl.handle.net/10361/18294
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The combined effect of Levofloxacin and Azithromycin against multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

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