Role of protein’s and future treatment options for Alzheimer’s Disease
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
| Hoofdauteur: | |
|---|---|
| Andere auteurs: | |
| Formaat: | Thesis |
| Taal: | English |
| Gepubliceerd in: |
Brac University
2023
|
| Onderwerpen: | |
| Online toegang: | http://hdl.handle.net/10361/18134 |
| id |
10361-18134 |
|---|---|
| record_format |
dspace |
| spelling |
10361-181342023-04-11T21:01:46Z Role of protein’s and future treatment options for Alzheimer’s Disease Islam, Md. Irfath Haque, Md. Aminul Department of Pharmacy, Brac University Alzheimer‘s disease APP Amyloid-beta Tau hyperphosphorylation Synaptic dysfunction Treatment Alzheimer's diseases--Treatment. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 40-52). Alzheimer‘s disease is a progressive brain disorder that slowly destroys the memorizing skill, decline in cognitive function and thinking ability which is one of the main causes of dementia. The exact cause of AD is still unknown but several studies suggest that extracellular accumulation of amyloid-beta oligomers and intracellular hyperphosphorylated tau peptides mainly responsible for this disease. Amyloid beta is 40-42 amino acid long polypeptide chain that is produced amyloid precursor protein through β-secretase and ɣ secretase enzymatic cleavage. Impaired amyloid accumulation causes synaptic dysfunction, mitochondrial dysfunction that cause neurodegeneration. Tau is intrinsically disordered protein which is required for stabilizing microtubules but hyperphosphorylation of tau protein cause them to dissociate from microtubules causes axonal loss. Acetylcholine esterase inhibitor and NMDA receptors antagonist are currently available drugs for AD that reduce AD symptoms. Currently scientists are working several AD drugs targeting the pathological hall marks of AD (Aβ and tau). Md. Irfath Islam B. Pharmacy 2023-04-11T03:54:11Z 2023-04-11T03:54:11Z 2022 2022-02 Thesis ID: 18146076 http://hdl.handle.net/10361/18134 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 52 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Alzheimer‘s disease APP Amyloid-beta Tau hyperphosphorylation Synaptic dysfunction Treatment Alzheimer's diseases--Treatment. |
| spellingShingle |
Alzheimer‘s disease APP Amyloid-beta Tau hyperphosphorylation Synaptic dysfunction Treatment Alzheimer's diseases--Treatment. Islam, Md. Irfath Role of protein’s and future treatment options for Alzheimer’s Disease |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Haque, Md. Aminul |
| author_facet |
Haque, Md. Aminul Islam, Md. Irfath |
| format |
Thesis |
| author |
Islam, Md. Irfath |
| author_sort |
Islam, Md. Irfath |
| title |
Role of protein’s and future treatment options for Alzheimer’s Disease |
| title_short |
Role of protein’s and future treatment options for Alzheimer’s Disease |
| title_full |
Role of protein’s and future treatment options for Alzheimer’s Disease |
| title_fullStr |
Role of protein’s and future treatment options for Alzheimer’s Disease |
| title_full_unstemmed |
Role of protein’s and future treatment options for Alzheimer’s Disease |
| title_sort |
role of protein’s and future treatment options for alzheimer’s disease |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/18134 |
| work_keys_str_mv |
AT islammdirfath roleofproteinsandfuturetreatmentoptionsforalzheimersdisease |
| _version_ |
1814309793509146624 |