A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| שפה: | English |
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Brac University
2023
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| גישה מקוונת: | http://hdl.handle.net/10361/18061 |
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10361-18061 |
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10361-180612023-04-03T21:01:53Z A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant Hossain, Ashraf Siam, Mohammad Kawsar Sharif Department of Pharmacy, Brac University In-silico Vibrio cholerae Antigenicity Vaccine design Molecular docking Cholera Vibrio infections Pharmaceutical technology Drugs--Design--Computer simulation This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 48-50). Cholera epidemic, history denotes it as “The Blue Death'', a deoxygenated, dehydrated death of humans due to the bacterial species named Vibrio Cholerae. When the sanitation system is extremely devastated by the purity of water and lacks the knowledge of hygiene, inhabitants make themselves vulnerable to this water and airborne microbe, Vibrio Cholerae. After getting affected by Vibrio Cholerae, a person gets desiccated due to water loss and infecting intestinal lumen (small and large intestine), if it stays untreated, the death of the person might occur in a few hours. Studying this severely spreading bacteria species and the extremity of the causing disease, an “In Silico'' approach is made to prepare a vaccine against Vibrio Cholerae. Several computational servers and tools were profoundly used during the preparation and justified their results. An In Silico'' approach is made to prepare a vaccine against Vibrio Cholerae. Several computational servers and tools were profoundly used during the preparation. The antigenicity result of the selected ""Outer Membrane Protein Sequence"" is 0.5469, stated as ""Probable ANTIGEN"". A proposed vaccine was then developed using linkers to be added and tested for antigenicity using Vaxijen V2.0 and the result was 0.6203. After that, the molecular docking was done using Patchdock and achieved a score of 20884 in a 3101.90 square angstrom region. Ashraf Hossain B. Pharmacy 2023-04-03T05:20:45Z 2023-04-03T05:20:45Z 2022 2022-10 Thesis ID 17346023 http://hdl.handle.net/10361/18061 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 50 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
In-silico Vibrio cholerae Antigenicity Vaccine design Molecular docking Cholera Vibrio infections Pharmaceutical technology Drugs--Design--Computer simulation |
| spellingShingle |
In-silico Vibrio cholerae Antigenicity Vaccine design Molecular docking Cholera Vibrio infections Pharmaceutical technology Drugs--Design--Computer simulation Hossain, Ashraf A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Siam, Mohammad Kawsar Sharif |
| author_facet |
Siam, Mohammad Kawsar Sharif Hossain, Ashraf |
| format |
Thesis |
| author |
Hossain, Ashraf |
| author_sort |
Hossain, Ashraf |
| title |
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| title_short |
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| title_full |
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| title_fullStr |
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| title_full_unstemmed |
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant |
| title_sort |
novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of o1 strain as adjuvant |
| publisher |
Brac University |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10361/18061 |
| work_keys_str_mv |
AT hossainashraf anovelvaccinedesigningapproachthroughanalyzingcomputationaltoolsagainstpathogenicvibriocholeraesoutermembraneproteinofo1strainasadjuvant AT hossainashraf novelvaccinedesigningapproachthroughanalyzingcomputationaltoolsagainstpathogenicvibriocholeraesoutermembraneproteinofo1strainasadjuvant |
| _version_ |
1814309370185383936 |