Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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Brac University
2022
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| 在线阅读: | http://hdl.handle.net/10361/17637 |
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10361-176372022-12-13T21:01:40Z Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma Raju, Md. Ismail Kabir, MD. Tanvir Department of Pharmacy, Brac University Glioblastoma AKT inhibition pathway Sorafenib Tumor cell proliferation Dephosphorylation Cancer cells This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 54-79). Glioblastoma multiforme is one of the common forms of brain cancer found worldwide, and treatment options are limited for this deadly disease. Various targeted treatments are being investigated, but no breakthroughs have yet been made. One of the most promising aspects of the glioblastoma treatment is the restriction of the intracellular signal transduction,also known asthe strain transformingpathway, and recently it has become the hotspot of brain cancer research. Sorafenib is a model drug that has shown signs of success in preclinical trials. Sorafenib, which is a multi-kinase inhibitor, induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3 and thus poses a promising aspect in developing a potential treatment of glioblastoma. This thesis report focuses on the use of sorafenib for the Protein kinase B (AKT) inhibition as a potential cure for glioblastoma. Md. Ismail Raju B. Pharmacy 2022-12-13T03:31:06Z 2022-12-13T03:31:06Z 2022 2022-03 Thesis ID 17346042 http://hdl.handle.net/10361/17637 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 79 pages application/pdf Brac University |
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Brac University |
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Institutional Repository |
| language |
English |
| topic |
Glioblastoma AKT inhibition pathway Sorafenib Tumor cell proliferation Dephosphorylation Cancer cells |
| spellingShingle |
Glioblastoma AKT inhibition pathway Sorafenib Tumor cell proliferation Dephosphorylation Cancer cells Raju, Md. Ismail Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Kabir, MD. Tanvir |
| author_facet |
Kabir, MD. Tanvir Raju, Md. Ismail |
| format |
Thesis |
| author |
Raju, Md. Ismail |
| author_sort |
Raju, Md. Ismail |
| title |
Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| title_short |
Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| title_full |
Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| title_fullStr |
Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| title_full_unstemmed |
Arresting tumor cell proliferation and inhibition of AKT pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| title_sort |
arresting tumor cell proliferation and inhibition of akt pathway via the use of multikinase inhibitor sorafenib forthe treatment of glioblastoma |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17637 |
| work_keys_str_mv |
AT rajumdismail arrestingtumorcellproliferationandinhibitionofaktpathwayviatheuseofmultikinaseinhibitorsorafenibforthetreatmentofglioblastoma |
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