Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
| Egile nagusia: | |
|---|---|
| Beste egile batzuk: | |
| Formatua: | Thesis |
| Hizkuntza: | English |
| Argitaratua: |
Brac University
2022
|
| Gaiak: | |
| Sarrera elektronikoa: | http://hdl.handle.net/10361/17625 |
| id |
10361-17625 |
|---|---|
| record_format |
dspace |
| spelling |
10361-176252022-12-04T21:01:37Z Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells Nandy, Aditi Alam, Marzia Department of Pharmacy, Brac University Myeloid derived suppressor cells Immunosuppressive mechanisms CD8+ T-cell responses Myeloid progenitor Lungs--Cancer This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis. Includes bibliographical references (pages 47-60). Myeloid derived suppressor cells or MDSC are immune cells derived from the common myeloid progenitor which is able to develop erythrocytes , platelets or other granulocytes .They are separated into two different subsets ; PMN-MDSC and M-MDSC . MDSCs inhibit the immune system and are involved in tumor maintenance and development. It also impede therapies that use immunotherapy or other non-immune methods to cure cancer. MDSCs were first identified as suppressors of T cells, namely CD8+ T-cell responses. The fact that MDSCs have a high number of immunosuppressive mechanisms does not imply that all of them are active at the same time. The type of MDSCs that multiplied in response to sickness, as well as the stage of the disease and the site of suppression, all influence the frequency of a particular immunosuppressive mechanism. MDSCs will most likely adopt a dominant suppressive mechanism at any one time, which will change as the disease advances. As a result, evaluating the significance of MDSCs in cancer should entail an examination of their functional activity as well as one or two chemicals produced by these cells. It also implies that targeting a single mechanism for therapeutic reasons may be ineffective unless that mechanism has been determined to be prevalent in the type of cancer being treated. Aditi Nandy B. Pharmacy 2022-12-04T06:31:42Z 2022-12-04T06:31:42Z 2022 2022-02 Thesis ID 17146017 http://hdl.handle.net/10361/17625 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 60 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Myeloid derived suppressor cells Immunosuppressive mechanisms CD8+ T-cell responses Myeloid progenitor Lungs--Cancer |
| spellingShingle |
Myeloid derived suppressor cells Immunosuppressive mechanisms CD8+ T-cell responses Myeloid progenitor Lungs--Cancer Nandy, Aditi Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Alam, Marzia |
| author_facet |
Alam, Marzia Nandy, Aditi |
| format |
Thesis |
| author |
Nandy, Aditi |
| author_sort |
Nandy, Aditi |
| title |
Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| title_short |
Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| title_full |
Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| title_fullStr |
Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| title_full_unstemmed |
Lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| title_sort |
lung cancer immunosuppression and therapeutic targeting of myeloid- derived suppressor cells |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17625 |
| work_keys_str_mv |
AT nandyaditi lungcancerimmunosuppressionandtherapeutictargetingofmyeloidderivedsuppressorcells |
| _version_ |
1814309210874183680 |