Epigenetic dysregulation in neurodegenerative diseases and potential treatment
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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Brac University
2022
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| Mynediad Ar-lein: | http://hdl.handle.net/10361/17309 |
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10361-173092022-09-26T21:02:08Z Epigenetic dysregulation in neurodegenerative diseases and potential treatment Mostofa, Golam Khan, Tanisha Tabassum Sayka Department of Pharmacy, Brac University Epigenetics Dysregulation Methylation Acetylation Alzheimer’s disease Parkinson’s disease Huntington’s disease Epidrugs This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 56-63). Epigenetics holds significant relevance in the contemporary neuroscience and has been associated with the pathogenesis of different neurodegenerative disorders. Epigenetic modifications including DNA methylation and histone acetylation have been widely studied in context of transcriptional regulation and dysregulation. In Alzheimer’s disease, presenilin 1 expression is significantly increased from DNA hypomethylation, thereby increasing the amyloid β peptide deposition. In Parkinson’s disease, decreased methylation increases the expression of α-synuclein and leads to SNCA protein accumulation. In Huntington’s disease, mutant Huntingtin reduces the functioning of histone acetyltransferases, resulting in the transcriptional dysregulations. In this literature review, the role of epigenetic deregulation in the development of neurodegenerative disorders was discussed followed by an insight on the potential of epigenetics-based treatment for these neurodegenerative disorders. Golam Mostofa B. Pharmacy 2022-09-26T06:25:04Z 2022-09-26T06:25:04Z 2022 2022-04 Thesis ID 18146021 http://hdl.handle.net/10361/17309 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 63 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Epigenetics Dysregulation Methylation Acetylation Alzheimer’s disease Parkinson’s disease Huntington’s disease Epidrugs |
| spellingShingle |
Epigenetics Dysregulation Methylation Acetylation Alzheimer’s disease Parkinson’s disease Huntington’s disease Epidrugs Mostofa, Golam Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Khan, Tanisha Tabassum Sayka |
| author_facet |
Khan, Tanisha Tabassum Sayka Mostofa, Golam |
| format |
Thesis |
| author |
Mostofa, Golam |
| author_sort |
Mostofa, Golam |
| title |
Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| title_short |
Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| title_full |
Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| title_fullStr |
Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| title_full_unstemmed |
Epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| title_sort |
epigenetic dysregulation in neurodegenerative diseases and potential treatment |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17309 |
| work_keys_str_mv |
AT mostofagolam epigeneticdysregulationinneurodegenerativediseasesandpotentialtreatment |
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1814309714077417472 |