A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| Dil: | English |
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Brac University
2022
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| Online Erişim: | http://hdl.handle.net/10361/17304 |
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10361-173042022-09-26T21:02:02Z A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme Chowdhury, Shamima Zerin Jamiruddin, Mohd Raeed Department of Pharmacy, Brac University Temozolomide Radiotherapy Overall survival Progression-free survival Vascular endothelial growth factor receptor Glioblastoma multiforme Gliomas This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 94-105). Glioblastoma multiforme is one of the most dangerous primary brain tumors, with a poor prognosis even after vigorous treatment. Neurosurgical enhancements, the discovery of potent chemotherapeutic medicines, developments in radiation and innovations in targeted delivery have all contributed to an increase in the extension of survival in patients. This systematic review incorporates 12 clinical trials and presents a concise evaluation of studies where temozolomide, radiotherapy along with other drugs are used in collaboration to treat glioblastoma and efficacy outcomes, rate of tolerability, and patient life expectancy are recorded, investigated, and reviewed to discover which combination treatment leads to an extended survival time or minimal side effects in patients. High dose radiation and TMZ had the longest OS and PFS with moderate toxicity. (Temozolomide+ Radiation+ 06 Benzylguanine + Carmustine + Plerixafor) also had the longest median OS and the fewest adverse effects, indicating that the study was effective. Although it considerably increased patient survival, (TMZ+ radiation + TSC) had the lowest amount of toxicity. (Temozolomide+ irinotecan+ bevacizumab) showed the highest rate of side effects, despite having a good OS and PFS. Shamima Zerin Chowdhury B. Pharmacy 2022-09-26T05:29:25Z 2022-09-26T05:29:25Z 2022 2022-03 Thesis ID 17346018 http://hdl.handle.net/10361/17304 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 113 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Temozolomide Radiotherapy Overall survival Progression-free survival Vascular endothelial growth factor receptor Glioblastoma multiforme Gliomas |
| spellingShingle |
Temozolomide Radiotherapy Overall survival Progression-free survival Vascular endothelial growth factor receptor Glioblastoma multiforme Gliomas Chowdhury, Shamima Zerin A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Jamiruddin, Mohd Raeed |
| author_facet |
Jamiruddin, Mohd Raeed Chowdhury, Shamima Zerin |
| format |
Thesis |
| author |
Chowdhury, Shamima Zerin |
| author_sort |
Chowdhury, Shamima Zerin |
| title |
A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| title_short |
A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| title_full |
A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| title_fullStr |
A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| title_full_unstemmed |
A systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| title_sort |
systematic review on the comparison of the safety and efficacy of temozolomide and radiotherapy along with another drug combination in the treatment of glioblastoma multiforme |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17304 |
| work_keys_str_mv |
AT chowdhuryshamimazerin asystematicreviewonthecomparisonofthesafetyandefficacyoftemozolomideandradiotherapyalongwithanotherdrugcombinationinthetreatmentofglioblastomamultiforme AT chowdhuryshamimazerin systematicreviewonthecomparisonofthesafetyandefficacyoftemozolomideandradiotherapyalongwithanotherdrugcombinationinthetreatmentofglioblastomamultiforme |
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1814308476555362304 |