A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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| التنسيق: | أطروحة |
| اللغة: | English |
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Brac University
2022
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10361/17300 |
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10361-17300 |
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10361-173002022-09-26T21:01:57Z A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer Islam, Nurjahan Jamiruddin, Mohd. Raeed Department of Pharmacy, Brac University Metastatic colorectal cancer FOLFIRI mFOLFOX6 Epidermal growth factor receptor Vascular endothelial growth factor receptor Rectum--Cancer--Treatment This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 54-68). Metastatic colorectal cancer is a leading cause of cancer death. FOLFIRI and FOLFOX based chemotherapies are known as first line treatments of metastatic colorectal cancer and they are used widely. In this systematic review, a search of PubMed, Google Scholar and www.ClinicalTrials.gov were conducted in order to find the data. Association between efficacy, adverse effects, outcomes and targets of drugs used for the treatment of metastatic colorectal cancer were systematically identified. The study included 13 clinical trials that comprised 2021 patients who received the FOLFIRI and FOLFOX based chemotherapies. Among all the FOLFIRI based chemotherapies, AFLIBERCEPT plus FOLFIRI based combination had higher PFS, higher OS and lower adverse effects. On the other hand, patients receiving panitumumab Plus mFOLFOX6 combination had higher ORR and higher median PFS in comparison to other mFOLFOX6 based chemotherapies. However, AFLIBERCEPT plus FOLFIRI based combination was more efficient but less effective than Panitumumab Plus mFOLFOX6 combination. Nurjahan Islam B. Pharmacy 2022-09-26T04:43:48Z 2022-09-26T04:43:48Z 2022 2022-03 Thesis ID 16346004 http://hdl.handle.net/10361/17300 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 82 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Metastatic colorectal cancer FOLFIRI mFOLFOX6 Epidermal growth factor receptor Vascular endothelial growth factor receptor Rectum--Cancer--Treatment |
| spellingShingle |
Metastatic colorectal cancer FOLFIRI mFOLFOX6 Epidermal growth factor receptor Vascular endothelial growth factor receptor Rectum--Cancer--Treatment Islam, Nurjahan A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Jamiruddin, Mohd. Raeed |
| author_facet |
Jamiruddin, Mohd. Raeed Islam, Nurjahan |
| format |
Thesis |
| author |
Islam, Nurjahan |
| author_sort |
Islam, Nurjahan |
| title |
A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| title_short |
A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| title_full |
A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| title_fullStr |
A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| title_full_unstemmed |
A systematic review on the comparison of FOLFIRI and FOLFOX based chemotherapies in the treatment of metastatic colorectal Cancer |
| title_sort |
systematic review on the comparison of folfiri and folfox based chemotherapies in the treatment of metastatic colorectal cancer |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17300 |
| work_keys_str_mv |
AT islamnurjahan asystematicreviewonthecomparisonoffolfiriandfolfoxbasedchemotherapiesinthetreatmentofmetastaticcolorectalcancer AT islamnurjahan systematicreviewonthecomparisonoffolfiriandfolfoxbasedchemotherapiesinthetreatmentofmetastaticcolorectalcancer |
| _version_ |
1814308476219817984 |