A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Brac University
2022
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10361/17254 |
| id |
10361-17254 |
|---|---|
| record_format |
dspace |
| spelling |
10361-172542022-09-21T21:01:43Z A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer Rahman, Tazin Akter, Raushanara Department of Pharmacy, Brac University High-grade serous ovarian cancer SIRT6 NOTCH3 Wnt/β-catenin EMT Tumorigenesis Ovaries--Cancer This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 44-54). High-grade serous ovarian cancer (HGSOC) is the most common type of ovarian cancer, accounting for about 70% of all ovarian cancer patients. Despite limited advancements in its treatment over the last decade, few standard therapies are currently available, although the survival rate remains poor. Currently available treatment for HGSOC is employing PARP inhibitors, anti-angiogenic, platinum-based chemotherapy, combination therapy with carboplatin and paclitaxel, etc. Increasing knowledge about the biology and pathways of SIRT6 led to the development of a new promising therapeutic target for HGSOC. SIRT6 can be a novel approach to treat HGSOC by regulating several cellular signaling pathways, including NOTCH3 and Wnt/β-catenin. Down-regulation of SIRT6 is associated with HGSOC and thus, up-regulation of SIRT6 by therapeutic modulators can be efficiently implemented to eradicate HGSOC. This review summarizes the current knowledge about SIRT6, its association with HGSOC, and the mechanisms for targeting SIRT6 to treat high-grade serous ovarian cancer. Tazin Rahman B. Pharmacy 2022-09-21T06:22:30Z 2022-09-21T06:22:30Z 2022 2022-03 Thesis ID 18146081 http://hdl.handle.net/10361/17254 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 54 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
High-grade serous ovarian cancer SIRT6 NOTCH3 Wnt/β-catenin EMT Tumorigenesis Ovaries--Cancer |
| spellingShingle |
High-grade serous ovarian cancer SIRT6 NOTCH3 Wnt/β-catenin EMT Tumorigenesis Ovaries--Cancer Rahman, Tazin A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Akter, Raushanara |
| author_facet |
Akter, Raushanara Rahman, Tazin |
| format |
Thesis |
| author |
Rahman, Tazin |
| author_sort |
Rahman, Tazin |
| title |
A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| title_short |
A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| title_full |
A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| title_fullStr |
A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| title_full_unstemmed |
A review on the role of histone deacetylase SIRT6 in high-grade serous ovarian Cancer |
| title_sort |
review on the role of histone deacetylase sirt6 in high-grade serous ovarian cancer |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17254 |
| work_keys_str_mv |
AT rahmantazin areviewontheroleofhistonedeacetylasesirt6inhighgradeserousovariancancer AT rahmantazin reviewontheroleofhistonedeacetylasesirt6inhighgradeserousovariancancer |
| _version_ |
1814309573943623680 |