Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
| Tác giả chính: | |
|---|---|
| Tác giả khác: | |
| Định dạng: | Luận văn |
| Ngôn ngữ: | English |
| Được phát hành: |
Brac University
2022
|
| Những chủ đề: | |
| Truy cập trực tuyến: | http://hdl.handle.net/10361/17251 |
| id |
10361-17251 |
|---|---|
| record_format |
dspace |
| spelling |
10361-172512022-09-21T21:01:41Z Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease Tanin, Nahid Sultana Rahman, Kazi Fatema Department of Pharmacy, Brac University Dopaminergic neurons α-synuclein aggregation Mitochondrial dysfunction Induced pluripotent stem cells 3D organoids Gene editing tools Cell reprogramming Cell transplantation therapy Parkinson's disease Cell transplantation This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 47-56). Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons primarily affecting the substantia nigra pars compacta, leading to a deficiency of dopamine in the striatum. Currently, existing treatments of PD only provide symptomatic relief and a permanent cure is yet to be discovered. Although animal models have provided valuable insights into the pathophysiology underlying PD, they are unable to recapitulate the full range of symptoms of human PD mainly due to species differences. These factors highlight an important clinical unmet need for developing cellular models of PD to study pathogenic mechanisms in-depth and identify potential drug targets. iPSCs provide a unique platform to model certain human diseases in vitro and offer the potential to develop cell-transplantation therapies as an innovative treatment strategy for PD. This comprehensive review discusses the utilization of patient-specific iPSCs to study disease mechanisms at a molecular level and discusses the challenges and potential solutions to overcome them. Nahid Sultana Tanin B. Pharmacy 2022-09-21T05:53:54Z 2022-09-21T05:53:54Z 2022 2022-03 Thesis ID 18146069 http://hdl.handle.net/10361/17251 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 56 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Dopaminergic neurons α-synuclein aggregation Mitochondrial dysfunction Induced pluripotent stem cells 3D organoids Gene editing tools Cell reprogramming Cell transplantation therapy Parkinson's disease Cell transplantation |
| spellingShingle |
Dopaminergic neurons α-synuclein aggregation Mitochondrial dysfunction Induced pluripotent stem cells 3D organoids Gene editing tools Cell reprogramming Cell transplantation therapy Parkinson's disease Cell transplantation Tanin, Nahid Sultana Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Rahman, Kazi Fatema |
| author_facet |
Rahman, Kazi Fatema Tanin, Nahid Sultana |
| format |
Thesis |
| author |
Tanin, Nahid Sultana |
| author_sort |
Tanin, Nahid Sultana |
| title |
Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| title_short |
Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| title_full |
Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| title_fullStr |
Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| title_full_unstemmed |
Induced pluripotent stem cells: a novel tool for modelling and treating Parkinson’s disease |
| title_sort |
induced pluripotent stem cells: a novel tool for modelling and treating parkinson’s disease |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17251 |
| work_keys_str_mv |
AT taninnahidsultana inducedpluripotentstemcellsanoveltoolformodellingandtreatingparkinsonsdisease |
| _version_ |
1814309713893916672 |