Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020.
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| Idioma: | English |
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Brac University
2022
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| Acesso em linha: | http://hdl.handle.net/10361/17038 |
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10361-170382022-07-25T21:01:41Z Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection Ahmed, Ashfaq Mostaid, Md. Shaki Department of Pharmacy, Brac University ROS Covid-19 Thrombosis Von Willebrand factor Hypercholesterolemia OxLDL COVID-19 (Disease) This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 33-60). The unprecedented emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put an enormous challenge to the healthcare system worldwide due to the lack of specific treatment options. Several studies found that patients with COVID-19 infection are developing thrombosis. There is a desperate need of understanding the mechanism by which COVID-19 infection is causing the generation of such thrombotic events. In this review, we suggest that excessive production of ROS induces endothelial cell dysfunction which results the release of von Willebrand factor. High von Willebrand factor leads to thrombus production. We also argue that hypercholesterolemia is a life-threatening comorbidity as it can influence thrombus formation by overwhelming production of OxLDL in the presence of COVID-19 infection. Lastly, we present drugs that are suitable in these conditions and their possible drug-drug interaction with investigational antiviral agents used against COVID-19 infection. Ashfaq Ahmed B. Pharmacy 2022-07-25T06:26:14Z 2022-07-25T06:26:14Z 2020 2020-12 Thesis ID 16346014 http://hdl.handle.net/10361/17038 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 60 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
ROS Covid-19 Thrombosis Von Willebrand factor Hypercholesterolemia OxLDL COVID-19 (Disease) |
| spellingShingle |
ROS Covid-19 Thrombosis Von Willebrand factor Hypercholesterolemia OxLDL COVID-19 (Disease) Ahmed, Ashfaq Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. |
| author2 |
Mostaid, Md. Shaki |
| author_facet |
Mostaid, Md. Shaki Ahmed, Ashfaq |
| format |
Thesis |
| author |
Ahmed, Ashfaq |
| author_sort |
Ahmed, Ashfaq |
| title |
Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| title_short |
Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| title_full |
Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| title_fullStr |
Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| title_full_unstemmed |
Oxidative stress induced thrombosis and Hypercholesterolemic condition in COVID-19 infection |
| title_sort |
oxidative stress induced thrombosis and hypercholesterolemic condition in covid-19 infection |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/17038 |
| work_keys_str_mv |
AT ahmedashfaq oxidativestressinducedthrombosisandhypercholesterolemicconditionincovid19infection |
| _version_ |
1814306836285751296 |