Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial
This article was published in The European Journal of Health Economics by Springer Link [Copyright © 2020, The Author(s)] and the definite version is available at: https://doi.org/10.1007/s10198-020-01235-3 The Journal's website is at: https://link.springer.com/article/10.1007/s10198-020-01235-...
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| Sarrera elektronikoa: | http://hdl.handle.net/10361/16639 https://doi.org/10.1007/s10198-020-01235-3 |
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10361-166392022-05-19T21:01:29Z Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial Robles‑Zurita, Jose Antonio Briggs, Andrew Rana, Dikshyanta Quayyum, Zahidul Oldroyd, Keith G. Zeymer, Uwe Desch, Stefen de Waha‑Thiele, Suzanne Thiele, Holger Brac James P. Grant School of Public Health Culprit-shock trial Economic evaluation Pre-trial model Decision analytic modelling This article was published in The European Journal of Health Economics by Springer Link [Copyright © 2020, The Author(s)] and the definite version is available at: https://doi.org/10.1007/s10198-020-01235-3 The Journal's website is at: https://link.springer.com/article/10.1007/s10198-020-01235-3#citeas Background The CULPRIT-SHOCK trial compared two treatment strategies for patients with acute myocardial infarction and multivessel coronary artery disease complicated by cardiogenic shock: (a) culprit vessel only percutaneous coronary intervention (CO-PCI), with additional staged revascularisation if indicated, and (b) immediate multivessel PCI (MV-PCI). Methods A German societal and national health service perspective was considered for three diferent analyses. The cost utility analysis (CUA) estimated costs and quality adjusted life years (QALYs) based on a pre-trial decision analytic model taking a lifelong time horizon. In addition, a within trial CUA estimated QALYs and costs for 1 year. Finally, the cost efectiveness analysis (CEA) used the composite primary outcome, mortality and renal failure at 30-day follow-up, and the within trial costs. Econometric and survival analysis on the trial data was used for the estimation of the model parameters. Subgroup analysis was performed following an economic protocol. Results The lifelong CUA showed an incremental cost efectiveness ratio (ICER), CO-PCI vs. MV-PCI, of €7010 per QALY and a probability of CO-PCI being the most cost-efective strategy>64% at a €30,000 threshold. The ICER for the within trial CUA was €14,600 and the incremental cost per case of death/renal failure avoided at 30-day follow-up was €9010. Cost-efectiveness improved with patient age and for those without diabetes. Conclusions The estimates of cost-efectiveness for CO-PCI vs. MV-PCI have been shown to change depending on the time horizon and type of economic evaluation performed. The results favoured a long-term horizon analysis for avoiding underestimation of QALY gains from the CO-PCI arm. Published 2022-05-19T06:58:35Z 2022-05-19T06:58:35Z 2020 2020-10-07 Journal Article Robles-Zurita, J. A., Briggs, A., Rana, D., Quayyum, Z., Oldroyd, K. G., Zeymer, U., . . . Thiele, H. (2020). Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: The CULPRIT-SHOCK trial. European Journal of Health Economics, 21(8), 1197-1209. doi:10.1007/s10198-020-01235-3 http://hdl.handle.net/10361/16639 https://doi.org/10.1007/s10198-020-01235-3 en_US https://link.springer.com/article/10.1007/s10198-020-01235-3#citeas The European Journal of Health Economics application/pdf Springer Link |
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Brac University |
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Institutional Repository |
| language |
en_US |
| topic |
Culprit-shock trial Economic evaluation Pre-trial model Decision analytic modelling |
| spellingShingle |
Culprit-shock trial Economic evaluation Pre-trial model Decision analytic modelling Robles‑Zurita, Jose Antonio Briggs, Andrew Rana, Dikshyanta Quayyum, Zahidul Oldroyd, Keith G. Zeymer, Uwe Desch, Stefen de Waha‑Thiele, Suzanne Thiele, Holger Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| description |
This article was published in The European Journal of Health Economics by Springer Link [Copyright © 2020, The Author(s)] and the definite version is available at: https://doi.org/10.1007/s10198-020-01235-3 The Journal's website is at: https://link.springer.com/article/10.1007/s10198-020-01235-3#citeas |
| author2 |
Brac James P. Grant School of Public Health |
| author_facet |
Brac James P. Grant School of Public Health Robles‑Zurita, Jose Antonio Briggs, Andrew Rana, Dikshyanta Quayyum, Zahidul Oldroyd, Keith G. Zeymer, Uwe Desch, Stefen de Waha‑Thiele, Suzanne Thiele, Holger |
| format |
Journal Article |
| author |
Robles‑Zurita, Jose Antonio Briggs, Andrew Rana, Dikshyanta Quayyum, Zahidul Oldroyd, Keith G. Zeymer, Uwe Desch, Stefen de Waha‑Thiele, Suzanne Thiele, Holger |
| author_sort |
Robles‑Zurita, Jose Antonio |
| title |
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| title_short |
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| title_full |
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| title_fullStr |
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| title_full_unstemmed |
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT‑SHOCK trial |
| title_sort |
economic evaluation of culprit lesion only pci vs. immediate multivessel pci in acute myocardial infarction complicated by cardiogenic shock: the culprit‑shock trial |
| publisher |
Springer Link |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/16639 https://doi.org/10.1007/s10198-020-01235-3 |
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