Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020.
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Brac University
2022
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| Länkar: | http://hdl.handle.net/10361/16606 |
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10361-166062022-05-16T21:01:37Z Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method Mow, Farhana Afrin Afrose, Afrina Department of Pharmacy, Brac University Ibuprofen Excipient Sodium Lauryl Sulphate Pluronic Dissolution rate Crystallization method Ibuprofen -- therapeutic use This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 49-54). Ibuprofen is widely used NSAID which deals with the treatment of mild to moderate pain formulated in various dosage forms. But poor water solubility and poor bioavailability is the drawback of this drug. So currently available marketed dosage forms are given with a high dose and it can cause adverse reactions in long term use. Lactose, Sodium Lauryl Sulphate (SLS) & Pluronic can enhance the dissolution rate of ibuprofen because all those excipients can enhance the solubility profile of ibuprofen in water. The comparison effect among these three excipients can be observed also. Precipitation crystallization technique is used to prepare ibuprofen particles to reduce the amount of dose. The experiment is done into two phase; particle preparation method (Crystallization) and dissolution method. The different dissolution time point indicates different dissolution rate for different excipients. All those contribute in lowering dose and increased the dissolution rate of ibuprofen in developed dosage forms like capsule. Farhana Afrin Mow B. Pharmacy 2022-05-16T05:19:00Z 2022-05-16T05:19:00Z 2020 2020-01 Thesis ID 14146009 http://hdl.handle.net/10361/16606 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 56 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Ibuprofen Excipient Sodium Lauryl Sulphate Pluronic Dissolution rate Crystallization method Ibuprofen -- therapeutic use |
| spellingShingle |
Ibuprofen Excipient Sodium Lauryl Sulphate Pluronic Dissolution rate Crystallization method Ibuprofen -- therapeutic use Mow, Farhana Afrin Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. |
| author2 |
Afrose, Afrina |
| author_facet |
Afrose, Afrina Mow, Farhana Afrin |
| format |
Thesis |
| author |
Mow, Farhana Afrin |
| author_sort |
Mow, Farhana Afrin |
| title |
Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| title_short |
Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| title_full |
Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| title_fullStr |
Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| title_full_unstemmed |
Comparison of lactose, Sodium Lauryl Sulphate (SLS) & Pluonic in dissolution profile of Ibuprofen prepared by crystallization method |
| title_sort |
comparison of lactose, sodium lauryl sulphate (sls) & pluonic in dissolution profile of ibuprofen prepared by crystallization method |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/16606 |
| work_keys_str_mv |
AT mowfarhanaafrin comparisonoflactosesodiumlaurylsulphateslspluonicindissolutionprofileofibuprofenpreparedbycrystallizationmethod |
| _version_ |
1814309786255097856 |