Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh
This article was published in the Journal of Nutrition [© 2018 American Society for Nutrition. All rights reserved. ] and the definite version is available at: https://doi.org/10.1093/jn/nxy161 The Journal's website is at: https://academic.oup.com/jn/article/148/10/1615/5094778?login=false
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Oxford Academic
2022
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| Accès en ligne: | http://hdl.handle.net/10361/16434 https://doi.org/10.1093/jn/nxy161 |
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10361-164342022-03-22T04:55:41Z Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh Matias, Susana L Mridha, Malay K Young, Rebecca T Hussain, Sohrab Dewey, Kathryn G Brac James P. Grant School of Public Health Lipid-Based Nutrient Supplements Iron and Folic Acid Supplements Hemoglobin Anemia Iron Deficiency Pregnant Women Lactating Women Infants Bangladesh This article was published in the Journal of Nutrition [© 2018 American Society for Nutrition. All rights reserved. ] and the definite version is available at: https://doi.org/10.1093/jn/nxy161 The Journal's website is at: https://academic.oup.com/jn/article/148/10/1615/5094778?login=false Background Maternal anemia and iron deficiency are prevalent in low- and middle-income countries. Objective We aimed to determine the effects of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on hemoglobin (Hb), anemia, and iron status (nonprimary outcomes) at 36 weeks of gestation (women) and 6 mo postpartum (women and infants). Methods The Rang-Din Nutrition Study, a cluster-randomized effectiveness trial, enrolled 4011 Bangladeshi pregnant women at ≤20 weeks of gestation to receive either daily LNS-PL (20 mg Fe) during pregnancy and the first 6 mo postpartum, or iron and folic acid (IFA, 60 mg Fe + 400 µg folic acid) daily during pregnancy and every other day during the first 3 mo postpartum. Biochemical measurements from a subsample of women (n = 1128) and their infants (n = 1117) included Hb (g/L), serum ferritin (µg/L), and soluble transferrin receptor (sTfR; mg/L). Anemia was defined as maternal Hb <110 g/L at 36 weeks of gestation, <120 g/L at 6 mo postpartum, or infant Hb <105 g/L; iron deficiency (ID) was defined as ferritin <12 µg/L or elevated sTfR (>8.3 mg/L for women and >11 mg/L for infants). Results Compared with the IFA group, women in the LNS-PL group had lower ferritin (–6.2 µg/L; P < 0.001) and higher sTfR concentrations (+0.5 mg/L; P < 0.001), and higher risk of ID (OR = 1.93; P < 0.05) at 36 weeks of gestation but not at 6 mo postpartum, whereas no consistent differences were observed for Hb or anemia. Among infants at 6 mo, there were no group differences except for a lower risk of elevated sTfR (OR = 0.61; P < 0.05) in the LNS-PL group than in the IFA group. Conclusions Provision of LNS-PL including a lower dose of iron than what is recommended during pregnancy resulted in differences in maternal iron status in late pregnancy that disappeared by 6 mo postpartum, and caused no undesirable effects regarding anemia or iron status of infants. This trial was registered at clinicaltrials.gov as NCT01715038. Published 2022-03-09T06:18:53Z 2022-03-09T06:18:53Z 2018 2018-09-10 Journal Article Matias, S. L., Mridha, M. K., Young, R. T., Hussain, S., & Dewey, K. G. (2018). Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh. Journal of Nutrition, 148(10), 1615-1624. doi:10.1093/jn/nxy161 http://hdl.handle.net/10361/16434 https://doi.org/10.1093/jn/nxy161 en_US https://academic.oup.com/jn/article/148/10/1615/5094778?login=false The Journal of Nutrition application/pdf Oxford Academic |
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Brac University |
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Institutional Repository |
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en_US |
| topic |
Lipid-Based Nutrient Supplements Iron and Folic Acid Supplements Hemoglobin Anemia Iron Deficiency Pregnant Women Lactating Women Infants Bangladesh |
| spellingShingle |
Lipid-Based Nutrient Supplements Iron and Folic Acid Supplements Hemoglobin Anemia Iron Deficiency Pregnant Women Lactating Women Infants Bangladesh Matias, Susana L Mridha, Malay K Young, Rebecca T Hussain, Sohrab Dewey, Kathryn G Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| description |
This article was published in the Journal of Nutrition [© 2018 American Society for Nutrition. All rights reserved.
] and the definite version is available at: https://doi.org/10.1093/jn/nxy161 The Journal's website is at: https://academic.oup.com/jn/article/148/10/1615/5094778?login=false |
| author2 |
Brac James P. Grant School of Public Health |
| author_facet |
Brac James P. Grant School of Public Health Matias, Susana L Mridha, Malay K Young, Rebecca T Hussain, Sohrab Dewey, Kathryn G |
| format |
Journal Article |
| author |
Matias, Susana L Mridha, Malay K Young, Rebecca T Hussain, Sohrab Dewey, Kathryn G |
| author_sort |
Matias, Susana L |
| title |
Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| title_short |
Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| title_full |
Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| title_fullStr |
Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| title_full_unstemmed |
Daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in Bangladesh |
| title_sort |
daily maternal lipid-based nutrient supplementation with 20 mg iron, compared with iron and folic acid with 60 mg iron, resulted in lower iron status in late pregnancy but not at 6 months postpartum in either the mothers or their infants in bangladesh |
| publisher |
Oxford Academic |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/16434 https://doi.org/10.1093/jn/nxy161 |
| work_keys_str_mv |
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