Prospects of 3D bioprinting as a possible treatment for Cancer cachexia
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021.
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Brac University
2022
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| 在线阅读: | http://hdl.handle.net/10361/16365 |
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10361-163652022-03-01T21:01:32Z Prospects of 3D bioprinting as a possible treatment for Cancer cachexia Galib, Mustafa Naser, Iftekhar Bin Promon, Salman Khan Department of Mathematics and Natural Sciences, Brac University Cancer cachexia Muscle atrophy Tissue regeneration 3D Bioprinting Cancer -- Nutritional aspects. Cachexia -- Treatment. Three-dimensional printing. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021. Catalogued from PDF version of thesis. Includes bibliographical references (pages 35-53). Cancer cachexia is a multifactorial syndrome that is identified by ongoing muscle atrophy, along with functional impairment, anorexia, weakness, fatigue, anemia, reduced tolerance to antitumor-treatments. Ultimately, reducing the patients’ quality of life. Cachexia alone causes about 22-25% cancer deaths. This review covers the symptoms, mediators, available treatment and future prospects of 3D bioprinting for cancer cachexia. Studies about cachexia have shown several factors that drive this disease – protein breakdown, inflammatory cytokines activation and mitochondrial alteration. Even with proper nutrition, physical exercises, anti-inflammatory agents, chemotherapy and grafting attempts, standard treatment has been unsuccessful for cachexia. But use of 3D-bioprinting shows much promise compared to conventional methods by attempting to fabricate 3D-constructs mimicking the native muscle tissues. In this review, some 3D-bioprinting techniques with their advantages and drawbacks, along with their achievements and challenges in in-vivo applications have been discussed. Constructs with neural integration or muscle-tendon units aim to repair muscle atrophy. But it is still difficult to properly bio-print these complex muscles. Although progress can be made by developing new bio-inks or 3D-printers to fabricate high resolution constructs. Using secondary data, this review study shows prospects of why 3D-bioprinting can be a good alternate approach to fight cachexia. Mustafa Galib B. Biotechnology 2022-03-01T04:52:30Z 2022-03-01T04:52:30Z 2021 2021-07 Thesis ID 18136075 http://hdl.handle.net/10361/16365 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 53 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
Cancer cachexia Muscle atrophy Tissue regeneration 3D Bioprinting Cancer -- Nutritional aspects. Cachexia -- Treatment. Three-dimensional printing. |
| spellingShingle |
Cancer cachexia Muscle atrophy Tissue regeneration 3D Bioprinting Cancer -- Nutritional aspects. Cachexia -- Treatment. Three-dimensional printing. Galib, Mustafa Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021. |
| author2 |
Naser, Iftekhar Bin |
| author_facet |
Naser, Iftekhar Bin Galib, Mustafa |
| format |
Thesis |
| author |
Galib, Mustafa |
| author_sort |
Galib, Mustafa |
| title |
Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| title_short |
Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| title_full |
Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| title_fullStr |
Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| title_full_unstemmed |
Prospects of 3D bioprinting as a possible treatment for Cancer cachexia |
| title_sort |
prospects of 3d bioprinting as a possible treatment for cancer cachexia |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/16365 |
| work_keys_str_mv |
AT galibmustafa prospectsof3dbioprintingasapossibletreatmentforcancercachexia |
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1814309711057518592 |