The role of cryo-electron microscopy in anticancer drug discovery and development
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
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| Dil: | English |
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Brac University
2021
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| Online Erişim: | http://hdl.handle.net/10361/15767 |
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10361-15767 |
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10361-157672021-12-26T21:01:37Z The role of cryo-electron microscopy in anticancer drug discovery and development Alam, Jemima Yasmin, Hasina Department of Pharmacy, Brac University Cryo-EM Anticancer drug Drug discovery Macromolecular imaging Electron microscopy--Technique Cancer Drug resistance in cancer cells This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 54-70). Multidrug resistance in cancer treatment is one of the major causes of the increasing need for newer, potent, and safer anticancer drugs. The discovery and development of novel anticancer drugs are limited by the limitations of the older imaging techniques like X-ray crystallography and NMR spectroscopy. Cryo-electron microscopy is a new imaging technology for developing a near-atomic level structural image of biological-macromolecules, small drug-molecules, and drug-receptor binding complexes. This review paper aims to study the role of cryo-EM in the discovery and development of newer anticancer drugs. It also highlights the impactful findings in the oncology field having significance in the anticancer drug discovery process. These include structural analysis of 80S ribosome, microtubule, DNA-PK holoenzyme, HER2-mAbs complex, CD20-antibody complex, human p97, etc. The observation suggests that further extensive analysis and studies of these structures can lead to a breakthrough in cancer research and the development of novel anticancer drugs. Jemima Alam B. Pharmacy 2021-12-26T09:24:00Z 2021-12-26T09:24:00Z 2021 2021-04 Thesis ID 17146005 http://hdl.handle.net/10361/15767 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 70 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cryo-EM Anticancer drug Drug discovery Macromolecular imaging Electron microscopy--Technique Cancer Drug resistance in cancer cells |
| spellingShingle |
Cryo-EM Anticancer drug Drug discovery Macromolecular imaging Electron microscopy--Technique Cancer Drug resistance in cancer cells Alam, Jemima The role of cryo-electron microscopy in anticancer drug discovery and development |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Alam, Jemima |
| format |
Thesis |
| author |
Alam, Jemima |
| author_sort |
Alam, Jemima |
| title |
The role of cryo-electron microscopy in anticancer drug discovery and development |
| title_short |
The role of cryo-electron microscopy in anticancer drug discovery and development |
| title_full |
The role of cryo-electron microscopy in anticancer drug discovery and development |
| title_fullStr |
The role of cryo-electron microscopy in anticancer drug discovery and development |
| title_full_unstemmed |
The role of cryo-electron microscopy in anticancer drug discovery and development |
| title_sort |
role of cryo-electron microscopy in anticancer drug discovery and development |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/15767 |
| work_keys_str_mv |
AT alamjemima theroleofcryoelectronmicroscopyinanticancerdrugdiscoveryanddevelopment AT alamjemima roleofcryoelectronmicroscopyinanticancerdrugdiscoveryanddevelopment |
| _version_ |
1814309365109227520 |