Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021.
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Brac University
2021
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| Online Erişim: | http://hdl.handle.net/10361/15720 |
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10361-157202021-12-12T21:01:28Z Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach NASIFUZZAMAN, S M Naser, Iftekhar Bin Rakib-Uz-Zaman, S M Department of Mathematics and Natural Sciences, Brac University Envelope protein Reverse vaccinology Multi-epitope vaccine B cell CTL HTL Immunoinformatics approach Dengue viruses This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021. Catalogued from PDF version of thesis. Includes bibliographical references (pages 42-47). Every year during the rainy season in Bangladesh severe Dengue infection is widespread throughout the country. Aedes aegypti and Ae. Albopictus are the two vectors that are responsible for the transmission of the virus. Thousands of lives including infants, adults, and old people die and many suffer painful fever due to this infection. In some severe cases, the patients experience a drastic decrease in their platelet count which sometimes causes hemorrhage and eventually leads to death. To protect lives against the Dengue virus, vaccination is an effective method. In our study, we have designed a vaccine against the Dengue virus by reverse vaccinology method. We have developed our vaccine targeting the envelope protein since it is highly conserved and immunogenic. Our study was mainly focused on predicting the right B cell epitopes, Cytotoxic T cell epitopes, and Helper T cell epitopes. These epitopes will be the key component of the vaccine. Stimulation of these cells in the body will help to acquire both Humoral and Cell-mediated immunity. As our study followed a immunoinformatics approach we employed various online bioinformatics tools and servers for epitope prediction. S M NASIFUZZMAN B. Biotechnology 2021-12-12T05:50:14Z 2021-12-12T05:50:14Z 2021 2021-08 Thesis ID 17336015 http://hdl.handle.net/10361/15720 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 47 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Envelope protein Reverse vaccinology Multi-epitope vaccine B cell CTL HTL Immunoinformatics approach Dengue viruses |
| spellingShingle |
Envelope protein Reverse vaccinology Multi-epitope vaccine B cell CTL HTL Immunoinformatics approach Dengue viruses NASIFUZZAMAN, S M Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2021. |
| author2 |
Naser, Iftekhar Bin |
| author_facet |
Naser, Iftekhar Bin NASIFUZZAMAN, S M |
| format |
Thesis |
| author |
NASIFUZZAMAN, S M |
| author_sort |
NASIFUZZAMAN, S M |
| title |
Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| title_short |
Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| title_full |
Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| title_fullStr |
Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| title_full_unstemmed |
Developing a novel multi-epitope vaccine against Dengue virus targeting the Envelope protein using an Immunoinformatics approach |
| title_sort |
developing a novel multi-epitope vaccine against dengue virus targeting the envelope protein using an immunoinformatics approach |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/15720 |
| work_keys_str_mv |
AT nasifuzzamansm developinganovelmultiepitopevaccineagainstdenguevirustargetingtheenvelopeproteinusinganimmunoinformaticsapproach |
| _version_ |
1814308818051399680 |