A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
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Brac University
2021
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| Acesso em linha: | http://hdl.handle.net/10361/15531 |
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10361-155312021-10-25T21:01:20Z A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases Tasnim, Saida Masuma Khan, Tanisha Tabassum Sayka Kabir, Eva Rahman Department of Pharmacy, Brac University Ageing Cellular senescence Chronic disorders Senolytic drugs Apoptosis Cells--Aging Chronic diseases--Treatment This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 58-88). Cellular senescence can be described as a condition in which dividing of the cells stops permanently and undergo distinctive epigenetic modifications, including profound chromatin and secretory changes, resulting in the formation of senescent cells. Senescent cells accumulate in multiple tissues throughout the course of ageing and the formation of excessive senescent cells in various tissues results in numerous chronic disorders, tissue degradation, age-related diseases, and ageing of organs. This indicates that the removal of senescent cells can minimize ageing and thus serves as a potential target for therapeutic intervention. Senolytic drugs are substances that selectively cause senescent cell apoptosis. Several age-associated diseases including cardiac dysfunction, heart failure, atherosclerosis, liver diseases, osteoporosis, pulmonary fibrosis, Parkinson’s and Alzheimer’s disease have been shown to be mitigated by the use of senolytic agents in preclinical as well as clinical studies. Saida Masuma Tasnim B. Pharmacy 2021-10-25T05:20:37Z 2021-10-25T05:20:37Z 2021 2021-04 Thesis ID 17146002 http://hdl.handle.net/10361/15531 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 88 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Ageing Cellular senescence Chronic disorders Senolytic drugs Apoptosis Cells--Aging Chronic diseases--Treatment |
| spellingShingle |
Ageing Cellular senescence Chronic disorders Senolytic drugs Apoptosis Cells--Aging Chronic diseases--Treatment Tasnim, Saida Masuma A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. |
| author2 |
Khan, Tanisha Tabassum Sayka |
| author_facet |
Khan, Tanisha Tabassum Sayka Tasnim, Saida Masuma |
| format |
Thesis |
| author |
Tasnim, Saida Masuma |
| author_sort |
Tasnim, Saida Masuma |
| title |
A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| title_short |
A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| title_full |
A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| title_fullStr |
A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| title_full_unstemmed |
A review on cellular senescence and prospect of Senolytic drugs against chronic age-related diseases |
| title_sort |
review on cellular senescence and prospect of senolytic drugs against chronic age-related diseases |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/15531 |
| work_keys_str_mv |
AT tasnimsaidamasuma areviewoncellularsenescenceandprospectofsenolyticdrugsagainstchronicagerelateddiseases AT tasnimsaidamasuma reviewoncellularsenescenceandprospectofsenolyticdrugsagainstchronicagerelateddiseases |
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