A comprehensive bioinformatics analysis of BRAF in cancer

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.

Bibliographic Details
Main Author:	Ahmed, Bagdad
Other Authors:	Hossain, M. Zulfiquer
Format:	Thesis
Language:	English
Published:	Brac University 2021
Subjects:	BRAF TCGA GTEx Cancer Protein-protein interaction Druggability Cancer > Treatment
Online Access:	http://hdl.handle.net/10361/15526

id	10361-15526
record_format	dspace
spelling	10361-155262021-10-24T21:01:22Z A comprehensive bioinformatics analysis of BRAF in cancer Ahmed, Bagdad Hossain, M. Zulfiquer Department of Pharmacy, Brac University BRAF TCGA GTEx Cancer Protein-protein interaction Druggability Cancer--Treatment This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 39-43). BRAF is one of the most vital serine/ threonine-protein kinase proto-oncogenes that performs a crucial role in cellular proliferation, growth, signaling and secretion. By deregulation of this gene can lead to terrible consequences including cancer. By utilizing the available dataset from Genotype-Tissue Expression (GTEx) and the Cancer Genome Atlas database we found that BRAF is overexpressed among 12 cancers. Moreover, BRAF overexpression is common in the late stages of cancers. Thus, we can understand its complicity with cancer invasion and progression. Furthermore, the study divulges a set of cancer that has a short overall survival time (OS) and poor prognosis due to dysregulation of this gene. We found two specific cancers PRAD (Prostate adenocarcinoma) wherein BRAF is overexpressed and KIRC (Kidney Renal Clear Cell Carcinoma) that has BRAF lower expressed. Key nodes for both cancers generated by PPI networks and potential druggability for both concerns were shown. Considering this cancer as a new target and understanding the proper role of BRAF on them by further study can lead to new therapies for both cancers. Bagdad Ahmed B. Pharmacy 2021-10-24T08:50:49Z 2021-10-24T08:50:49Z 2021 2021-09 Thesis ID 17346015 http://hdl.handle.net/10361/15526 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 43 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	BRAF TCGA GTEx Cancer Protein-protein interaction Druggability Cancer--Treatment
spellingShingle	BRAF TCGA GTEx Cancer Protein-protein interaction Druggability Cancer--Treatment Ahmed, Bagdad A comprehensive bioinformatics analysis of BRAF in cancer
description	This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
author2	Hossain, M. Zulfiquer
author_facet	Hossain, M. Zulfiquer Ahmed, Bagdad
format	Thesis
author	Ahmed, Bagdad
author_sort	Ahmed, Bagdad
title	A comprehensive bioinformatics analysis of BRAF in cancer
title_short	A comprehensive bioinformatics analysis of BRAF in cancer
title_full	A comprehensive bioinformatics analysis of BRAF in cancer
title_fullStr	A comprehensive bioinformatics analysis of BRAF in cancer
title_full_unstemmed	A comprehensive bioinformatics analysis of BRAF in cancer
title_sort	comprehensive bioinformatics analysis of braf in cancer
publisher	Brac University
publishDate	2021
url	http://hdl.handle.net/10361/15526
work_keys_str_mv	AT ahmedbagdad acomprehensivebioinformaticsanalysisofbrafincancer AT ahmedbagdad comprehensivebioinformaticsanalysisofbrafincancer
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A comprehensive bioinformatics analysis of BRAF in cancer

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