Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
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| Định dạng: | Luận văn |
| Ngôn ngữ: | en_US |
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Brac University
2021
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| Truy cập trực tuyến: | http://hdl.handle.net/10361/15159 |
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10361-15159 |
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10361-151592021-10-06T21:01:24Z Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies Rahman, Md. Masudur Kabir, Eva Rahman Azad, Md Abul Kalam Department of Pharmacy, Brac University Domperidone Solubility Drug delivery strategy Pharmacokinetic Parameters Amorphization Drug-drug interactions This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 42-60). Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and extensive first-pass metabolism. Therefore, to develop its oral preparations with optimized absorption and bioavailability, the pharmacokinetic parameters of this drug need to be controlled. This study aims to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, explore the viable oral formulation approaches such as direct compression, amorphization, micronization, thin film preparation, pelletization etc. based on their pharmacokinetic parameters for determining the most valuable strategies and to provide adequate information in developing novel alternatives to the current commercial products. In this study, some effective strategies in this regard have comparatively discussed. It has been found that the amorphous solid dispersion approach could be more convincing from the scalability perspective along with its significant improvement in dissolution behavior and oral bioavailability. Finally, some future perspectives of these strategies have been addressed to facilitate efficient formulation development. Md. Masudur Rahman B. Pharmacy 2021-10-06T09:40:32Z 2021-10-06T09:40:32Z 2021. 2021-01 Thesis ID: 16346007 http://hdl.handle.net/10361/15159 en_US Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 60 Pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
en_US |
| topic |
Domperidone Solubility Drug delivery strategy Pharmacokinetic Parameters Amorphization Drug-drug interactions |
| spellingShingle |
Domperidone Solubility Drug delivery strategy Pharmacokinetic Parameters Amorphization Drug-drug interactions Rahman, Md. Masudur Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. |
| author2 |
Kabir, Eva Rahman |
| author_facet |
Kabir, Eva Rahman Rahman, Md. Masudur |
| format |
Thesis |
| author |
Rahman, Md. Masudur |
| author_sort |
Rahman, Md. Masudur |
| title |
Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| title_short |
Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| title_full |
Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| title_fullStr |
Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| title_full_unstemmed |
Domperidone: A literature based review on pharmacokinetic control using different drug delivery strategies |
| title_sort |
domperidone: a literature based review on pharmacokinetic control using different drug delivery strategies |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/15159 |
| work_keys_str_mv |
AT rahmanmdmasudur domperidonealiteraturebasedreviewonpharmacokineticcontrolusingdifferentdrugdeliverystrategies |
| _version_ |
1814309781600468992 |