Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana
This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021.
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Brac University
2021
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10361-150912021-10-03T21:01:24Z Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana Alvy, Raghib Ishraq Mubassir, M H M Department of Mathematics and Natural Sciences, Brac University Pattern Triggered Immunity Pattern Recognition Receptors MM/PBSA PAMP Molecular Dynamics Bioinformatics This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021. Catalogued from PDF version of thesis. Includes bibliographical references (pages 95-103). Pattern Triggered Immunity (PTI) is distinguished with the activities of pattern recognition receptors (PRRs), which play an essential role in plant defense mechanism. During aggression of microbes, PRRs immediately bind with the PAMPs and recruit co-receptors to initiate the defense signal. Several plant PRRs have been discovered, very few of their functional parameters have been studied. In this study, the crystallographic structures of FLS2-flg22-BAK1 (PDB ID: 4MN8), HAESA-IDA-SERK1 (PDB ID: 5IYX) and PSKR-Phytosulphokine-SERK1 (PDB ID: 4Z64) complexes were simulated for 30ns. Simulated trajectories were analyzed for getting an overview of the immune response of PRRs towards PAMPs with the help of co-receptors. Moreover, MM/PBSA calculation revealed that interaction between FLS2-BAK1 and HAESA-SERK1 show similarity whereas PSKR interacts differently with SERK1. As PRRs play a major role in plant defense mechanism, it can be hypothesized that binding mechanism with PAMPs and co-receptors will help to understand the interaction pattern of PTI. Raghib Ishraq Alvy M. Biotechnology 2021-10-03T05:12:37Z 2021-10-03T05:12:37Z 2021 2021-01 Thesis ID: 20376005 http://hdl.handle.net/10361/15091 en_US Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 104 Pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
en_US |
| topic |
Pattern Triggered Immunity Pattern Recognition Receptors MM/PBSA PAMP Molecular Dynamics Bioinformatics |
| spellingShingle |
Pattern Triggered Immunity Pattern Recognition Receptors MM/PBSA PAMP Molecular Dynamics Bioinformatics Alvy, Raghib Ishraq Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| description |
This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2021. |
| author2 |
Mubassir, M H M |
| author_facet |
Mubassir, M H M Alvy, Raghib Ishraq |
| format |
Thesis |
| author |
Alvy, Raghib Ishraq |
| author_sort |
Alvy, Raghib Ishraq |
| title |
Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| title_short |
Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| title_full |
Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| title_fullStr |
Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| title_full_unstemmed |
Structural analysis of three pivotal SERK dependent PRR complexes of Arabidopsis thaliana |
| title_sort |
structural analysis of three pivotal serk dependent prr complexes of arabidopsis thaliana |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/15091 |
| work_keys_str_mv |
AT alvyraghibishraq structuralanalysisofthreepivotalserkdependentprrcomplexesofarabidopsisthaliana |
| _version_ |
1814306874358497280 |