Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020.
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Brac University
2021
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| Online Zugang: | http://hdl.handle.net/10361/14833 |
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10361-148332021-07-27T21:01:30Z Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer Tabassum, Azwada Yasmin, Hasina Department of Pharmacy, Brac University In silico Molecular docking FAP-α Binding affinity Rectum--Cancer Colon (Anatomy)--Cancer This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 44-49). Being one of the leading cause of death worldwide, the fatality of colorectal cancer is increasing day by day causing approximately 862,000 deaths annually, according to IARC, 2020. As most of the conventional chemotherapeutics are becoming resistant, an in silico study was done using synthetic and natural small molecules to identify possible drug that may be proposed in the treatment of colorectal cancer. Because of having a significant role in the tumor progression of colorectal cancer, FAP-α was taken as the macromolecule. Molecular docking was performed and binding affinities were evaluated. Furthermore, the results were visualized by Discovery Studio to find out non-bonded ligand-protein interaction. At the end, admetSAR property of the drugs were assessed and compared with the standard drug. Therefore, analyzing all the in silico results, the selected drugs having the property of inhibiting FAP-α were proposed for the treatment of colorectal cancer. Azwada Tabassum B. Pharmacy 2021-07-27T14:42:40Z 2021-07-27T14:42:40Z 2020 2020-03 Thesis ID 16146004 http://hdl.handle.net/10361/14833 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 50 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
In silico Molecular docking FAP-α Binding affinity Rectum--Cancer Colon (Anatomy)--Cancer |
| spellingShingle |
In silico Molecular docking FAP-α Binding affinity Rectum--Cancer Colon (Anatomy)--Cancer Tabassum, Azwada Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Tabassum, Azwada |
| format |
Thesis |
| author |
Tabassum, Azwada |
| author_sort |
Tabassum, Azwada |
| title |
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| title_short |
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| title_full |
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| title_fullStr |
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| title_full_unstemmed |
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer |
| title_sort |
inhibition of fibroblast activation protein alpha (fap-α) in colorectal cancer |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14833 |
| work_keys_str_mv |
AT tabassumazwada inhibitionoffibroblastactivationproteinalphafapaincolorectalcancer |
| _version_ |
1814307268084105216 |