Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020.
| Príomhchruthaitheoir: | |
|---|---|
| Rannpháirtithe: | |
| Formáid: | Tráchtas |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Brac University
2021
|
| Ábhair: | |
| Rochtain ar líne: | http://hdl.handle.net/10361/14737 |
| id |
10361-14737 |
|---|---|
| record_format |
dspace |
| spelling |
10361-147372021-07-05T21:01:21Z Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity Aana, Afsara Sumon Kabir, Md. Tanvir Department of Pharmacy, Brac University Amyloid beta Tau protein PD-1 Autoimmunity Alzheimer's disease. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 35-47). Alzheimer’s disease is the most common type of neurodegenerative disorder oriented dementia which is regulated by chronic inflammation in brain cells. Nevertheless, repeated experiments with immunosuppressive agents had failures to treat AD, implementing immune checkpoint blockade to affect the pathogenesis of AD showed some lights of hope in animal model. These animal trials stated about the mitigation of neuronal inflammatory responses and diminution in amyloid beta plaque formation and decrease in Tau protein entanglement. The cognitive symptoms were also observed as falling down. A massive surprising change in the tau pathology was informed by these researches that the macrophages were increased within neuronal parenchyma. In general, almost all the relevant experiments stated that PD-1 and ligand targeted immune checkpoint blockade can modify the factors which help to progress AD or cognitive behaviors. So this pathway can help to combat this disease succefully. Afsara Sumon Aana B. Pharmacy 2021-07-05T15:24:05Z 2021-07-05T15:24:05Z 2020 2020-12 Thesis ID 16146032 http://hdl.handle.net/10361/14737 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 47 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Amyloid beta Tau protein PD-1 Autoimmunity Alzheimer's disease. |
| spellingShingle |
Amyloid beta Tau protein PD-1 Autoimmunity Alzheimer's disease. Aana, Afsara Sumon Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. |
| author2 |
Kabir, Md. Tanvir |
| author_facet |
Kabir, Md. Tanvir Aana, Afsara Sumon |
| format |
Thesis |
| author |
Aana, Afsara Sumon |
| author_sort |
Aana, Afsara Sumon |
| title |
Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| title_short |
Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| title_full |
Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| title_fullStr |
Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| title_full_unstemmed |
Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| title_sort |
exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14737 |
| work_keys_str_mv |
AT aanaafsarasumon exploringtheroleofprogrammedcelldeathprotein1inalzheimersdiseaseassociatedautoimmunity |
| _version_ |
1814309361351131136 |