Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019.
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Brac University
2021
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10361-143242021-03-08T21:01:20Z Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection Tabassum, Mehnaz Tareq, Tokee Mohammad Department of Mathematics and Natural Sciences, Brac University Bacteria Bacteriophages Phage therapy Anti-biotic Resistance Drug-resistance This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. Catalogued from PDF version of thesis. Includes bibliographical references (page 24). Bacteriophage therapy sheds a fresh light upon the critical growth of antibiotic resistance. Antimicrobial resistance, one of the major public health concerns, requires a novel therapeutic strategy to be optimized. Phage therapy is being renovated in this regard. Few of the main challenges include shifting the dynamics of the micro biome, selecting the most adequate phages, integrating the clinical phages as prophage, probable immune responses and regulatory requirements. The major drawback lies within the phage genome. Though phages carry a plethora of genes that confer fitness advantages to the bacterial community, these genes are highly variable from phage to phage. The presence of fitness factors with the possibility of recombination or horizontal gene transfer complicates the application of phages. Here, we assess the potential of phage therapy from a clinical perspective. The analysis will include the possibility of using phages with no biosafety concern. Considering the isolation techniques, the number of phages per bacterial host vary a lot, which will also be considered for individual bacterial species level. Such evaluation will help us to primarily evaluate the potential of using existing phages as an alternative of treating infectious diseases with multiple drug resistant bacteria. Mehnaz Tabassum B. Biotechnology 2021-03-08T06:16:31Z 2021-03-08T06:16:31Z 2019 2019-12 Thesis ID: 16136011 http://hdl.handle.net/10361/14324 en_US 24 Pages application/pdf Brac University |
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Brac University |
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Institutional Repository |
| language |
en_US |
| topic |
Bacteria Bacteriophages Phage therapy Anti-biotic Resistance Drug-resistance |
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Bacteria Bacteriophages Phage therapy Anti-biotic Resistance Drug-resistance Tabassum, Mehnaz Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. |
| author2 |
Tareq, Tokee Mohammad |
| author_facet |
Tareq, Tokee Mohammad Tabassum, Mehnaz |
| format |
Thesis |
| author |
Tabassum, Mehnaz |
| author_sort |
Tabassum, Mehnaz |
| title |
Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| title_short |
Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| title_full |
Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| title_fullStr |
Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| title_full_unstemmed |
Molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| title_sort |
molecular assessment of bacteriophage genome as a potential therapeutic agent in treating multi-drug resistant bacterial infection |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14324 |
| work_keys_str_mv |
AT tabassummehnaz molecularassessmentofbacteriophagegenomeasapotentialtherapeuticagentintreatingmultidrugresistantbacterialinfection |
| _version_ |
1814309046551838720 |