Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2020.
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Brac University
2021
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| 在线阅读: | http://hdl.handle.net/10361/14321 |
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10361-143212021-03-08T21:01:15Z Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance Hossain, Sayema Syeda Hossain, Mahboob Department of Mathematics and Natural Sciences, Brac University Bacteriophages Antibiotic Resistance Citrobacter freundii This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2020. Catalogued from PDF version of thesis. Includes bibliographical references (pages 50-55). Citrobacter freundii is a species of bacteria in the Enterobacteriaceae family that is known to cause hospital-acquired infections in the respiratory tract, urinary tract, blood, and other normally sterile sites in immunocompromised patients and is growing resistant to multiple antibiotics. In the current state of growing antibiotic resistance, phage therapy is one of the alternatives being explored. Two of the biggest concerns regarding phage therapy are the virus' ability to transfer antibiotic resistance or virulence genes through phage morons. After comparison using Linux based BLAST between complete Citrobacter phage genomes downloaded from the NCBI website and the Comprehensive Antibiotic Resistance Database and the Virulence Factor Database, it was determined that none of the 21 phages showed signs of carrying virulence or antibiotic resistance genes. Through phylogenetic tree construction using Linux based Roary and web-based ITOL, it was determined that there is a possibility of lysogeny in the phages Sayema Syeda Hossain B. Microbiology 2021-03-08T04:10:38Z 2021-03-08T04:10:38Z 2020 2020-02 Thesis ID: 13226005 http://hdl.handle.net/10361/14321 en_US Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 55 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
en_US |
| topic |
Bacteriophages Antibiotic Resistance Citrobacter freundii |
| spellingShingle |
Bacteriophages Antibiotic Resistance Citrobacter freundii Hossain, Sayema Syeda Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2020. |
| author2 |
Hossain, Mahboob |
| author_facet |
Hossain, Mahboob Hossain, Sayema Syeda |
| format |
Thesis |
| author |
Hossain, Sayema Syeda |
| author_sort |
Hossain, Sayema Syeda |
| title |
Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| title_short |
Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| title_full |
Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| title_fullStr |
Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| title_full_unstemmed |
Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance |
| title_sort |
safety assessment of citrobacter freundii bacteriophages for use in phage therapy in the face of antibiotic resistance |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14321 |
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AT hossainsayemasyeda safetyassessmentofcitrobacterfreundiibacteriophagesforuseinphagetherapyinthefaceofantibioticresistance |
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