Epigenetic therapy in cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2017.
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| Μορφή: | Thesis |
| Γλώσσα: | English |
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Brac University
2021
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| Διαθέσιμο Online: | http://hdl.handle.net/10361/14095 |
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10361-14095 |
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10361-140952021-03-07T05:55:32Z Epigenetic therapy in cancer Abid, Md. Shadman Ridwan Department of Pharmacy, Brac University Cancer This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2017. Epigenetic therapy has received much attention in the field of oncology in recent years. A growing recognition of the influence of epigenetic modifications in tumorigenesis and the clinical success of several drugs that reverse the aberrant epigenetic alterations have positioned epigenetic therapy at the forefront of anti-cancer drug development. Several epigenetic enzymes such as DNA methyltransferase, histone deacetylase, topoisomerase,and EZH2 have been successfully targeted by small molecule inhibitors. Potential epigenetic modifiers are continuously being optimized for bioavailability, half-life, metabolism, and most importantly target specificity. Discovery of new compounds has also broadened the pipeline of latest epi-drugs. Considering the prospect of success of epigenetic therapy against lethal malignancies, in this review we aspire to describe how different abnormal epigenetic patterns such as excessive DNA methylation, histone deacetylation, and defective chromatin remodeling contribute to cancer and present an overview of the current implementation of epi-drugs along with combined therapy in cancer treatment. B. Pharmacy 2021-02-03T06:28:28Z 2021-02-03T06:28:28Z 2017-07 Thesis ID 13146046 http://hdl.handle.net/10361/14095 en application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cancer |
| spellingShingle |
Cancer Abid, Md. Shadman Ridwan Epigenetic therapy in cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2017. |
| author2 |
Department of Pharmacy, Brac University |
| author_facet |
Department of Pharmacy, Brac University Abid, Md. Shadman Ridwan |
| format |
Thesis |
| author |
Abid, Md. Shadman Ridwan |
| author_sort |
Abid, Md. Shadman Ridwan |
| title |
Epigenetic therapy in cancer |
| title_short |
Epigenetic therapy in cancer |
| title_full |
Epigenetic therapy in cancer |
| title_fullStr |
Epigenetic therapy in cancer |
| title_full_unstemmed |
Epigenetic therapy in cancer |
| title_sort |
epigenetic therapy in cancer |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14095 |
| work_keys_str_mv |
AT abidmdshadmanridwan epigenetictherapyincancer |
| _version_ |
1814307795796754432 |