Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019.
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Brac University
2020
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10361-140132020-08-25T21:01:15Z Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa Salahuddin, Fariba Hossain, M. Mahboob Department of Mathematics and Natural Sciences, Brac University Cefixime Azithromycin Antibiotics resistant Klebsiella pneumoniae Pseudomonas aeruginosa This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. Cataloged from PDF version of thesis. Includes bibliographical references (pages 33-36). Pneumonia is a lung infection with a variety of possible causes. It can be a severe disease with an infection of bacteria, virus or fungus. The lungs are inflamed and the tiny air sacs become filled with fluid inside. Infants, young children and people over the age of 65 suffer most because they have a vulnerable immune system. Two major pathogens causing pneumonia that were studied are Klebsiella pneumoniae and Pseudomonas aeruginosa. The objective of the present study was to design a new method to manage antibiotic resistance against Klebsiella pneumoniae and Pseudomonas aeruginosa. A total of 30 bacterial samples of lung infection were studied against 10 antibiotics of different classes. The primary screening was accomplished with the combination of cefixime with other antibiotics to understand the synergistic effect. Cefixime disc combined with azithromycin antibiotic solution gave the synergistic effect. Furthermore, the minimum inhibitory concentration (MIC) was performed individually with cefixime and azithromycin. A high number of multidrug-resistant (MDR) Klebsiella pneumoniae and Pseudomonas aeruginosa showed more susceptibility to azithromycin compared to that of cefixime. Then the minimum inhibitory concentration (MIC) was generated combining both cefixime and azithromycin. Furthermore, the results were interpreted with FIC index after calculating the FIC (Fractional inhibitory concentration). Fariba Salahuddin B. Biotechnology 2020-08-25T13:47:32Z 2020-08-25T13:47:32Z 2019 2019-12 Thesis ID 16136033 http://hdl.handle.net/10361/14013 en_US Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 39 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
en_US |
| topic |
Cefixime Azithromycin Antibiotics resistant Klebsiella pneumoniae Pseudomonas aeruginosa |
| spellingShingle |
Cefixime Azithromycin Antibiotics resistant Klebsiella pneumoniae Pseudomonas aeruginosa Salahuddin, Fariba Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. |
| author2 |
Hossain, M. Mahboob |
| author_facet |
Hossain, M. Mahboob Salahuddin, Fariba |
| format |
Thesis |
| author |
Salahuddin, Fariba |
| author_sort |
Salahuddin, Fariba |
| title |
Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| title_short |
Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| title_full |
Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| title_fullStr |
Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| title_full_unstemmed |
Combined effect of Cefixime and Azithromycin against multiple antibiotics resistant Klebsiella pneumoniae and Pseudomonas aeruginosa |
| title_sort |
combined effect of cefixime and azithromycin against multiple antibiotics resistant klebsiella pneumoniae and pseudomonas aeruginosa |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/14013 |
| work_keys_str_mv |
AT salahuddinfariba combinedeffectofcefiximeandazithromycinagainstmultipleantibioticsresistantklebsiellapneumoniaeandpseudomonasaeruginosa |
| _version_ |
1814309495153623040 |