Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
| Автор: | |
|---|---|
| Інші автори: | |
| Формат: | Дисертація |
| Мова: | English |
| Опубліковано: |
Brac University
2020
|
| Предмети: | |
| Онлайн доступ: | http://hdl.handle.net/10361/13939 |
| id |
10361-13939 |
|---|---|
| record_format |
dspace |
| spelling |
10361-139392020-08-11T21:01:19Z Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract Khan, Mujtaba Ali Akter, Raushanara Department of Pharmacy, Brac University Antioxidant Cytotoxic Free radical Phenolic Flavonoid Medicinal plants Materia medica, Vegetable This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 69-89). Blumea lacera (family: Asteraceae) is a very potent plant for its various therapeutic properties. This research was intended to detect the antioxidant and cytotoxic potential of chloroform extract of this plant leaf. Antioxidant potential was assessed by a number of in-vitro antioxidant studies and among them DPPH free radical scavenging assay showed 86.43% inhibition of free radicals at 1200μg/mL of the extract with IC50 of 2.39μg/mL. Highest total phenolic content (TPC), total flavonoid content (TFC) and total antioxidant capacity (TAC) was found to be 285.47mg of GAE/g, 287.12mg of QE/g and 272.21mg of AAE/g at 1200μg/mL of extract, respectively. Cytotoxic activity was measured using in-vitro MTT assay against HeLa and MOLT-4 cell lines that showed IC50 of 3.46mg/mL and 3.29mg/mL for the extract. These results showed that the extract had strong antioxidant and low cytotoxic potential. Mujtaba Ali Khan Mujtaba Ali Khan B. Pharmacy 2020-08-11T12:36:19Z 2020-08-11T12:36:19Z 2019 2019-10 Thesis ID 15346039 http://hdl.handle.net/10361/13939 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 89 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antioxidant Cytotoxic Free radical Phenolic Flavonoid Medicinal plants Materia medica, Vegetable |
| spellingShingle |
Antioxidant Cytotoxic Free radical Phenolic Flavonoid Medicinal plants Materia medica, Vegetable Khan, Mujtaba Ali Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Akter, Raushanara |
| author_facet |
Akter, Raushanara Khan, Mujtaba Ali |
| format |
Thesis |
| author |
Khan, Mujtaba Ali |
| author_sort |
Khan, Mujtaba Ali |
| title |
Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| title_short |
Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| title_full |
Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| title_fullStr |
Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| title_full_unstemmed |
Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract |
| title_sort |
investigation of in-vitro antioxidant and cytotoxic activity of blumea lacera leaf extract |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13939 |
| work_keys_str_mv |
AT khanmujtabaali investigationofinvitroantioxidantandcytotoxicactivityofblumealaceraleafextract |
| _version_ |
1814309358754856960 |