Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
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Brac University
2020
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| Acceso en liña: | http://hdl.handle.net/10361/13924 |
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10361-13924 |
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10361-139242020-08-08T21:01:20Z Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent Hossain, Rubaiya Afrose, Afrina Department of Pharmacy, Brac University Poloxamer 407 L-leucine Solubility Ibuprofen Medicine Immunology This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 46-56). Ibuprofen is a drug with very poor aqueous solubility and high permeability. Its poor aqueous solubility is one of the major problems when formulating a dosage form with it. This study was conducted by considering its poor aqueous solubility and solely concentrated on increasing the solubility. In this study the solubility of ibuprofen was examined by dissolution method using water, 10% ethanol and 20% ethanol as solvents. Poloxamer 407 and L-leucine were used as excipients. The whole study was conducted at 25ºC. Ibuprofen was found to show a significant enhancement in solubility in addition with poloxamer 407 in three of the solvent system up to a certain poloxamer 407 concentration (2%). L-leucine did not affect the solubility of ibuprofen significantly, the increment in the solubility were irregular. Rubaiya Hossain Department of Pharmacy, Brac University B. Pharmacy 2020-08-08T14:02:06Z 2020-08-08T14:02:06Z 2019 2019-08 Thesis ID 15146089 http://hdl.handle.net/10361/13924 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 62 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Poloxamer 407 L-leucine Solubility Ibuprofen Medicine Immunology |
| spellingShingle |
Poloxamer 407 L-leucine Solubility Ibuprofen Medicine Immunology Hossain, Rubaiya Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| description |
This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019. |
| author2 |
Afrose, Afrina |
| author_facet |
Afrose, Afrina Hossain, Rubaiya |
| format |
Thesis |
| author |
Hossain, Rubaiya |
| author_sort |
Hossain, Rubaiya |
| title |
Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| title_short |
Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| title_full |
Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| title_fullStr |
Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| title_full_unstemmed |
Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent |
| title_sort |
solubility of ibuprofen with poloxamer 407 and l-leucine in water and ethanol co-solvent |
| publisher |
Brac University |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10361/13924 |
| work_keys_str_mv |
AT hossainrubaiya solubilityofibuprofenwithpoloxamer407andlleucineinwaterandethanolcosolvent |
| _version_ |
1814309199022129152 |